SUV39H2

Suv39h1 and Suv39h2 govern methylation of histone H3 Lys9 (H3-Lys9) in heterochromatic regions.

suppressor of variegation 3-9 homolog 2

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to hypoxiaManual Assertion Based On ExperimentIDA:MGI
Biological Process chromatin organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process chromatin remodelingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process histone H3-K9 dimethylationISS:UniProtKB
Biological Process histone H3-K9 trimethylationISS:UniProtKB
Biological Process histone lysine methylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of circadian rhythmISS:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:MGI
Biological Process rhythmic processIEA:UniProtKB-KW

Nucleus
Chromosome, centromere
Associates with centromeric constitutive heterochromatin.