SYMPK

This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq]
Full Name
symplekin
Function
Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.
Biological Process
Biological Process cell adhesionIEA:UniProtKB-KW
Biological Process mRNA polyadenylationIMP:UniProtKB1 Publication
Biological Process negative regulation of protein bindingIMP:UniProtKB1 Publication
Biological Process positive regulation of protein dephosphorylationIDA:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Cell junction, tight junction
Cell membrane
Cell junction
Nucleus, nucleoplasm
Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells. Colocalizes with HSF1 in nuclear stress bodies upon heat shock (PubMed:14707147).
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Anti-SYMPK antibodies

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Rabbit Anti-SYMPK Recombinant Antibody (D5Y3T) (CBMAB-CP2657-LY)

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Target: SYMPK
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Dog, Horse
Clone: D5Y3T
Application*: WB, IP
Datasheet SDS

Mouse Anti-SYMPK Recombinant Antibody (4C2) (CBMAB-A8800-LY)

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Target: SYMPK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4C2
Application*: WB, E
Datasheet SDS

Mouse Anti-SYMPK Recombinant Antibody (Sym-TJ-E150) (CBMAB-S6648-CQ)

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Target: SYMPK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Sym-TJ-E150
Application*: IH, WB
Datasheet SDS

Mouse Anti-SYMPK Recombinant Antibody (CBXS-2173) (CBMAB-S4936-CQ)

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Target: SYMPK
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2173
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-SYMPK Recombinant Antibody (CBXS-5415) (CBMAB-S2627-CQ)

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Target: SYMPK
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey, Dog, Horse
Clone: CBXS-5415
Application*: WB, IP
Datasheet SDS

Mouse Anti-SYMPK Recombinant Antibody (CBXS-5001) (CBMAB-S2223-CQ)

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Target: SYMPK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-5001
Application*: E, IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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