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Mouse Anti-SYMPK Recombinant Antibody (CBXS-5001) (CBMAB-S2223-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5001
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IHC-P, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-534 from SYMPK (AAH30214) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
symplekin
Introduction
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.
Entrez Gene ID
8189
UniProt ID
Q92797
Alternative Names
SPK; SYM
Function
Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.
Biological Process
Biological Process cell adhesionIEA:UniProtKB-KW
Biological Process mRNA polyadenylationIMP:UniProtKB1 Publication
Biological Process negative regulation of protein bindingIMP:UniProtKB1 Publication
Biological Process positive regulation of protein dephosphorylationIDA:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Cell junction, tight junction
Cell membrane
Cell junction
Nucleus, nucleoplasm
Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells. Colocalizes with HSF1 in nuclear stress bodies upon heat shock (PubMed:14707147).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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