TAX1BP3

TAX1BP3 is a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. TAX1BP3 interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. TAX1BP3 was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. TAX1BP3 also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, TAX1BP3 has been shown to function in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Tax1 (human T-cell leukemia virus type I) binding protein 3

May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.

Biological Process activation of GTPase activityIDA:BHF-UCL1 Publication
Biological Process negative regulation of cell population proliferationIEA:Ensembl
Biological Process negative regulation of protein localization to cell surfaceIDA:UniProtKB1 Publication
Biological Process negative regulation of Wnt signaling pathwayISS:UniProtKB
Biological Process Rho protein signal transductionIDA:UniProtKB1 Publication
Biological Process Wnt signaling pathwayIEA:UniProtKB-KW

Cytoplasm
Nucleus
Cell membrane
Recruited to the cell membrane by interaction with membrane proteins.