Trem3

Trem3 is part of the immunoglobulin and lectin-like superfamily and is thought to play a role as part of the innate immune system. Trem3 forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. It has been reported to associate with the adaptor protein Dap-12 to form a receptor signaling complex that activates myeloid cells.

Full Name

Triggering Receptor Expressed On Myeloid Cells 3

Function

Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response.

Biological Process

Biological Process cell migration Source:MGI1 Publication
Biological Process neutrophil chemotaxis Source:MGI1 Publication
Biological Process neutrophil extravasation Source:MGI1 Publication
Biological Process neutrophil-mediated killing of gram-negative bacterium Source:MGI1 Publication
Biological Process positive regulation of innate immune response Source:UniProtKB1 Publication

Cellular Location

Cell membrane

Topology

Extracellular: 20-138
Helical: 139-159
Cytoplasmic: 160-183

Anti-Trem3 antibodies

Rat Anti-Trem3 Recombinant Antibody (CBYJT-4617) (CBMAB-T4146-YJ)

Datasheet

SDS

Target: Trem3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBYJT-4617

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)