Trem3

Trem3 is part of the immunoglobulin and lectin-like superfamily and is thought to play a role as part of the innate immune system. Trem3 forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. It has been reported to associate with the adaptor protein Dap-12 to form a receptor signaling complex that activates myeloid cells.

Full Name

Triggering Receptor Expressed On Myeloid Cells 3

Function

Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response.

Biological Process

Biological Process cell migration Source:MGI1 Publication
Biological Process neutrophil chemotaxis Source:MGI1 Publication
Biological Process neutrophil extravasation Source:MGI1 Publication
Biological Process neutrophil-mediated killing of gram-negative bacterium Source:MGI1 Publication
Biological Process positive regulation of innate immune response Source:UniProtKB1 Publication

Cellular Location

Cell membrane

Topology

Extracellular: 20-138
Helical: 139-159
Cytoplasmic: 160-183