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Rat Anti-Trem3 Recombinant Antibody (CBYJT-4617) (CBMAB-T4146-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Trem3 (Triggering Receptor Expressed On Myeloid Cells 3). The antibody can be used for immunoassay techniques, such as WB.
See all Trem3 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-4617
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse TREM-3 Met1-Pro135 (predicted)
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 5% Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-135

Target

Full Name
Triggering Receptor Expressed On Myeloid Cells 3
Introduction
Trem3 is part of the immunoglobulin and lectin-like superfamily and is thought to play a role as part of the innate immune system. Trem3 forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. It has been reported to associate with the adaptor protein Dap-12 to form a receptor signaling complex that activates myeloid cells.
Entrez Gene ID
58218
UniProt ID
Q9JKE1
Alternative Names
TREM-3; BB134760
Function
Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response.
Biological Process
Biological Process cell migration Source:MGI1 Publication
Biological Process neutrophil chemotaxis Source:MGI1 Publication
Biological Process neutrophil extravasation Source:MGI1 Publication
Biological Process neutrophil-mediated killing of gram-negative bacterium Source:MGI1 Publication
Biological Process positive regulation of innate immune response Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 20-138
Helical: 139-159
Cytoplasmic: 160-183
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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