TRPM8

TRPM8 (Transient Receptor Potential Cation Channel Subfamily M Member 8) is a Protein Coding gene. Diseases related to TRPM8 include Prostate Cancer and Lichen Sclerosus Et Atrophicus. Among its related pathways are CREB Pathway and Development Endothelin-1/EDNRA signaling. Gene Ontology (GO) annotations related to TRPM8 include protein homodimerization activity and calcium channel activity. An important paralog of TRPM8 is TRPM2.

Transient Receptor Potential Cation Channel Subfamily M Member 8

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186).
Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.

Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process cation transmembrane transport Source:GO_Central1 Publication
Biological Process cellular calcium ion homeostasis Source:Ensembl
Biological Process detection of temperature stimulus Source:InterPro
Biological Process positive regulation of cold-induced thermogenesis Source:YuBioLabBy Similarity
Biological Process response to cold Source:Ensembl
Biological Process thermoception Source:Ensembl

Cell membrane
Membrane raft
Endoplasmic reticulum membrane
Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity).
Located in the endoplasmic reticulum in prostate cancer cells

Cytoplasmic: 1-691
Helical: 692-712
Extracellular: 713-734
Helical: 735-755
Cytoplasmic: 756-759
Helical: 760-780
Extracellular: 781-794
Helical: 795-815
Cytoplasmic: 816-829
Helical: 830-850
Extracellular: 851-958
Helical: 959-979
Cytoplasmic: 980-1104