Sign in or Register   Sign in or Register
  |  

Mouse Anti-TRPM8 Recombinant Antibody (CBYJT-4922) (CBMAB-T4476-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRPM8 (Transient Receptor Potential Cation Channel Subfamily M Member 8). The antibody can be used for immunoassay techniques, such as WB, ELISA, ICC.
See all TRPM8 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
CBYJT-4922
Antibody Isotype
IgG1
Application
WB, ELISA, ICC

Basic Information

Specificity
Human, Rat, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transient Receptor Potential Cation Channel Subfamily M Member 8
Introduction
TRPM8 (Transient Receptor Potential Cation Channel Subfamily M Member 8) is a Protein Coding gene. Diseases related to TRPM8 include Prostate Cancer and Lichen Sclerosus Et Atrophicus. Among its related pathways are CREB Pathway and Development Endothelin-1/EDNRA signaling. Gene Ontology (GO) annotations related to TRPM8 include protein homodimerization activity and calcium channel activity. An important paralog of TRPM8 is TRPM2.
Entrez Gene ID
Human79054
Mouse171382
Rat171384
UniProt ID
HumanQ7Z2W7
MouseQ8R4D5
RatQ8R455
Alternative Names
Transient Receptor Potential Cation Channel Subfamily M Member 8; Transient Receptor Potential P8; LTrpC-6; Trp-P8; LTRPC6; TRPP8
Function
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186).
Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.
Biological Process
Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process cation transmembrane transport Source:GO_Central1 Publication
Biological Process cellular calcium ion homeostasis Source:Ensembl
Biological Process detection of temperature stimulus Source:InterPro
Biological Process positive regulation of cold-induced thermogenesis Source:YuBioLabBy Similarity
Biological Process response to cold Source:Ensembl
Biological Process thermoception Source:Ensembl
Cellular Location
Cell membrane
Membrane raft
Endoplasmic reticulum membrane
Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity).
Located in the endoplasmic reticulum in prostate cancer cells
Topology
Cytoplasmic: 1-691
Helical: 692-712
Extracellular: 713-734
Helical: 735-755
Cytoplasmic: 756-759
Helical: 760-780
Extracellular: 781-794
Helical: 795-815
Cytoplasmic: 816-829
Helical: 830-850
Extracellular: 851-958
Helical: 959-979
Cytoplasmic: 980-1104
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TRPM8 Recombinant Antibody (CBYJT-4922)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare