ZNF385A

Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).

Full Name

zinc finger protein 385A

Function

RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.

Biological Process

Biological Process apoptotic process Source:UniProtKB
Biological Process cellular response to DNA damage stimulus Source:UniProtKB
Biological Process hemostasis Source:Ensembl
Biological Process learning or memory Source:Ensembl
Biological Process locomotory behavior Source:Ensembl
Biological Process megakaryocyte development Source:UniProtKB
Biological Process mRNA localization resulting in post-transcriptional regulation of gene expression Source:UniProtKB
Biological Process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source:UniProtKB1 Publication
Biological Process platelet alpha granule organization Source:Ensembl
Biological Process platelet formation Source:Ensembl
Biological Process positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source:UniProtKB1 Publication
Biological Process positive regulation of fat cell differentiation Source:UniProtKB
Biological Process regulation of cytoplasmic translation Source:UniProtKB

Cellular Location

Cytoplasm
Nucleus, nucleolus
Cell projection, dendrite
Note: Detected in dendrites of Purkinje cells and hippocampal neurons.

PTM

Ubiquitinated upon prolonged exposure to genotoxic stress, which leads to proteasomal degradation of ZNF385A and releases p53/TP53 from cell-cycle arrest target gene promoters.