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Mouse Anti-ZNF385A Recombinant Antibody (1H9) (CBMAB-0816-LY)

This product is mouse antibody recognizes ZNF385A of human. The antibody 1H9 immunoassay techniques such as: IP, ELISA.
See all ZNF385A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H9
Antibody Isotype
IgG2a
Application
IP, ELISA

Basic Information

Immunogen
Full length
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
zinc finger protein 385A
Introduction
Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins. RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity.
Entrez Gene ID
25946
UniProt ID
Q96PM9
Alternative Names
DKFZp586G1122; Hzf; ZFP385; ZNF385
Function
RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.
Biological Process
Biological Process apoptotic process Source:UniProtKB
Biological Process cellular response to DNA damage stimulus Source:UniProtKB
Biological Process hemostasis Source:Ensembl
Biological Process learning or memory Source:Ensembl
Biological Process locomotory behavior Source:Ensembl
Biological Process megakaryocyte development Source:UniProtKB
Biological Process mRNA localization resulting in post-transcriptional regulation of gene expression Source:UniProtKB
Biological Process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source:UniProtKB1 Publication
Biological Process platelet alpha granule organization Source:Ensembl
Biological Process platelet formation Source:Ensembl
Biological Process positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source:UniProtKB1 Publication
Biological Process positive regulation of fat cell differentiation Source:UniProtKB
Biological Process regulation of cytoplasmic translation Source:UniProtKB
Cellular Location
Cytoplasm
Nucleus, nucleolus
Cell projection, dendrite
Note: Detected in dendrites of Purkinje cells and hippocampal neurons.
PTM
Ubiquitinated upon prolonged exposure to genotoxic stress, which leads to proteasomal degradation of ZNF385A and releases p53/TP53 from cell-cycle arrest target gene promoters.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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