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CD33

CD33 (CD33 Molecule) is a Protein Coding gene. Diseases associated with CD33 include Gallbladder Lymphoma and Extracutaneous Mastocytoma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is SIGLEC6.
Full Name
CD33 Molecule
Function
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212).
Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872).
Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109).
These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109).
In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed:10206955, PubMed:10887109).
One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed:15597323).
Biological Process
Cell adhesion Source: GO_Central
Cell-cell adhesion Source: ARUK-UCL
Cell-cell signaling Source: ProtInc
Immune response-inhibiting signal transduction Source: UniProtKB
Negative regulation of calcium ion transport Source: ARUK-UCL
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of interleukin-1 beta production Source: ARUK-UCL
Negative regulation of interleukin-8 production Source: ARUK-UCL
Negative regulation of monocyte activation Source: ARUK-UCL
Negative regulation of tumor necrosis factor production Source: ARUK-UCL
Neutrophil degranulation Source: Reactome
Positive regulation of protein secretion Source: UniProtKB
Positive regulation of protein tyrosine phosphatase activity Source: ARUK-UCL
Regulation of immune response Source: Reactome
Signal transduction Source: ProtInc
Cellular Location
Isoform CD33M: Cell membrane
Isoform CD33m: Peroxisome. CD33m isoform does not localize to cell surfaces but instead accumulates in peroxisomes.
Topology
Extracellular: 18-259
Helical: 260-282
Cytoplasmic: 283-364
PTM
Glycosylated. Glycosylation at Asn-100 is critical for regulating ligand recognition.
Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. LCK phosphorylates Tyr-340 efficiently and Tyr-358 to a lesser extent.

Anti-CD33 antibodies

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Mouse Anti-CD33 Recombinant Antibody (CB057) (CBMAB-CS057LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB057
Application*: IF, FC

Mouse Anti-CD33 Recombinant Antibody (CB056) (CBMAB-CS056LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB056
Application*: IF, FC

Mouse Anti-CD33 Recombinant Antibody (CB055) (CBMAB-CS055LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB055
Application*: IF, FC

Rabbit Anti-CD33 Recombinant Antibody (001) (CBMAB-C0013-LY)

Datasheet SDS
Target: CD33
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 001
Application*: E, F

Mouse Anti-CD33 Recombinant Antibody (06) (CBMAB-C0087-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 06
Application*: E, F

Mouse Anti-CD33 Recombinant Antibody (09) (CBMAB-C0100-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 09
Application*: F

Mouse Anti-CD33 Recombinant Antibody (2C6B7) (CBMAB-C0849-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C6B7
Application*: E, WB, P, IF/C, F

Mouse Anti-CD33 Recombinant Antibody (CBXS-1891) (CBMAB-S0051-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1891
Application*: F

Mouse Anti-CD33 Recombinant Antibody (CBXS-5653) (CBMAB-S0050-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-5653
Application*: WB, IH, P

Mouse Anti-CD33 Recombinant Antibody (14i100) (CBMAB-C3033-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14i100
Application*: E, F, C, WB

Mouse Anti-CD33 Recombinant Antibody (1B10) (CBMAB-C3609-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B10
Application*: IF, WB

Mouse Anti-CD33 Recombinant Antibody (1E4) (CBMAB-C3946-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E4
Application*: WB

Mouse Anti-CD33 Recombinant Antibody (C33/68) (CBMAB-C4612-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C33/68
Application*: FN, F, IF

Mouse Anti-CD33 Recombinant Antibody (HIM3-4) (CBMAB-C4611-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: HIM3-4
Application*: F

Mouse Anti-CD33 Recombinant Antibody (CBXC-2038) (CBMAB-C4607-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2038
Application*: WB

Mouse Anti-CD33 Recombinant Antibody (WM53) (CBMAB-C2252-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: WM53
Application*: F

Human Anti-CD33 Recombinant Antibody (CBXC-0929) (CBMAB-C2045-CQ)

Datasheet SDS
Target: CD33
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0929
Application*: F

Mouse Anti-CD33 Recombinant Antibody (CBYY-C1322) (CBMAB-C2760-YY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C1322
Application*: C

Mouse Anti-CD33 Recombinant Antibody (CBYY-C1321) (CBMAB-C2759-YY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1321
Application*: WB

Mouse Anti-CD33 Recombinant Antibody (CBYY-C1319) (CBMAB-C2757-YY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1319
Application*: F, IH, IP, WB

Mouse Anti-CD33 Recombinant Antibody (CBYY-C1318) (CBMAB-C2756-YY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1318
Application*: F, WB

Mouse Anti-CD33 Recombinant Antibody (2C1) (CBMAB-C4737-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C1
Application*: P, WB

Mouse Anti-CD33 Recombinant Antibody (2D12-G4) (CBMAB-C4871-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D12-G4
Application*: E, WB

Mouse Anti-CD33 Recombinant Antibody (CBYY-C0389) (CBMAB-C1305-YY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0389
Application*: F, IF, IH

Mouse Anti-CD33 (AA 337-364) Recombinant Antibody (574CT16.4.4) (CBMAB-C1111-YY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 574CT16.4.4
Application*: E, WB, IF

Mouse Anti-CD33 Recombinant Antibody (2G8) (CBMAB-C5217-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2G8
Application*: WB

Mouse Anti-CD33 Recombinant Antibody (44M12D3) (CBMAB-C6500-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 44M12D3
Application*: WB, IH, P

Mouse Anti-CD33 Recombinant Antibody (5C24) (CBMAB-C7378-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5C24
Application*: C, WB

Mouse Anti-CD33 Recombinant Antibody (5F31) (CBMAB-C7607-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F31
Application*: F, IF, IH

Mouse Anti-CD33 Recombinant Antibody (3D6) (CBMAB-C5886-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: 3D6
Application*: E

Mouse Anti-CD33 Recombinant Antibody (6C5/2) (CBMAB-C8126-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6C5/2
Application*: E, P, F

Mouse Anti-CD33 Recombinant Antibody (7G8) (CBMAB-C8738-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7G8
Application*: WB

Mouse Anti-CD33 Recombinant Antibody (906 MY9) (CBMAB-C9308-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 906 MY9
Application*: C

Recombinant Mouse Anti-CD33 Recombinant Antibody (1C7/1) (CBMAB-XB0163-YC)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C7/1
Application*: E, WB

Mouse Anti-CD33 Recombinant Antibody (5K280) (CBMAB-C0294-CN)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5K280
Application*: FC, IH, IP, WB

Mouse Anti-CD33 Recombinant Antibody (13B127) (CBMAB-C1670-CN)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B127
Application*: E, WB

Mouse Anti-CD33 Recombinant Antibody (2Q1302) (CBMAB-C1672-CN)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q1302
Application*: FC

Mouse Anti-CD33 Recombinant Antibody (MY9) (CBMAB-C1676-CN)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: MY9
Application*: IH, IP, FC

Rabbit Anti-CD33 Recombinant Antibody (SP266) (CBMAB-C1677-CN)

Datasheet SDS
Target: CD33
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP266
Application*: WB, FC, P

Mouse Anti-CD33 Recombinant Antibody (P67.6) (CBMAB-C10189-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: P67.6
Application*: F

Mouse Anti-CD33 Recombinant Antibody (TBM3) (CBMAB-C10191-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TBM3
Application*: IF/IC, C

Rabbit Anti-CD33 Recombinant Antibody (CBR061G) (CBMAB-BT018LY)

Datasheet SDS
Target: CD33
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR061G
Application*: WB, IP, IHC

Mouse Anti-CD33 Recombinant Antibody (CBXS-2578) (CBMAB-S5334-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2578
Application*: WB

Mouse Anti-CD33 Recombinant Antibody (PWS44) (CBMAB-C4617-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: PWS44
Application*: IH

Mouse Anti-CD33 Recombinant Antibody (CBXC-2119) (CBMAB-C4616-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2119
Application*: WB, IF

Mouse Anti-CD33 Recombinant Antibody (CBXC-1917) (CBMAB-C4614-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1917
Application*: E

Mouse Anti-CD33 Recombinant Antibody (CBYY-C1317) (CBMAB-C2755-YY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: CBYY-C1317
Application*: E

Rat Anti-CD33 Recombinant Antibody (CBYY-C0739) (CBMAB-C2175-YY)

Datasheet SDS
Target: CD33
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-C0739
Application*: F

Mouse Anti-CD33 Recombinant Antibody (CBYY-C0107) (CBMAB-C0444-YY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0107
Application*: F

Mouse Anti-CD33 Recombinant Antibody (CBFYC-1217) (CBMAB-C1275-FY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1217
Application*: IF, WB

Rabbit Anti-CD33 Recombinant Antibody (CBFYC-0075) (CBMAB-C0084-FY)

Datasheet SDS
Target: CD33
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0075
Application*: E, F

Mouse Anti-CD33 Recombinant Antibody (CBFYC-0073) (CBMAB-C0082-FY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0073
Application*: E, F

Mouse Anti-CD33 Recombinant Antibody (CBFYM-0447) (CBMAB-M0563-FY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0447
Application*: F

Mouse Anti-CD33 Recombinant Antibody (2B7C12) (CBMAB-EN633-LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2B7C12
Application*: WB, ELISA

Mouse Anti-CD33 Recombinant Antibody (A045) (CBMAB-AP10666LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A045
Application*: FC

Mouse Anti-CD33 Recombinant Antibody (C33/69) (CBMAB-AP1031LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C33/69
Application*: FA, FC, IF

Mouse Anti-CD33 Recombinant Antibody (FOS) (CBMAB-AP1028LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: FOS
Application*: FC

Mouse Anti-CD33 Recombinant Antibody (CB060) (CBMAB-CS060LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB060
Application*: IF, FC

Mouse Anti-CD33 Recombinant Antibody (CB059) (CBMAB-CS059LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB059
Application*: IF, FC

Mouse Anti-CD33 Recombinant Antibody (CB058) (CBMAB-CS058LY)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB058
Application*: IF, FC

Rat Anti-CD33 Recombinant Antibody (CBXS-1981) (CBMAB-S4751-CQ)

Datasheet SDS
Target: CD33
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXS-1981
Application*: WB

Mouse Anti-CD33 Recombinant Antibody (CBXS-4455) (CBMAB-S1697-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4455
Application*: WB, F, E, IH, P, MC

Mouse Anti-CD33 Recombinant Antibody (CBXS-4424) (CBMAB-S1666-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4424
Application*: WB, IH

Mouse Anti-CD33 Recombinant Antibody (CBXS-4850) (CBMAB-S0056-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4850
Application*: E

Mouse Anti-CD33 Recombinant Antibody (CBXS-3940) (CBMAB-S0055-CQ)

Datasheet SDS
Target: CD33
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3940
Application*: WB, E

CD33 Matched Antibody Pair (217) (APMAB-217LY)

Datasheet SDS
Target: CD33
Specificity: Human

CD33 Matched Antibody Pair (219) (APMAB-219LY)

Datasheet SDS
Target: CD33
Specificity: Human

CD33 Matched Antibody Pair (218) (APMAB-218LY)

Datasheet SDS
Target: CD33
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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