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CD33 Matched Antibody Pair (218) (APMAB-218LY)

This antibody pair set can be used for detecting and quantifying protein level of human CD33.
See all CD33 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-CD33 polyclonal antibody, 100 ug
Detection Antibody
Anti-CD33 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
CD33 (CD33 Molecule) is a Protein Coding gene. Diseases associated with CD33 include Gallbladder Lymphoma and Extracutaneous Mastocytoma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is SIGLEC6.
Alternative Names
CD33 Molecule; Sialic Acid-Binding Ig-Like Lectin 3; CD33 Antigen (Gp67); SIGLEC-3; SIGLEC3; Gp67;
Entrez Gene ID
945
UniProt ID
P20138

Marcinek, A., Brauchle, B., Hänel, G., Lacher, S. M., Zieger, N., Kischel, R., ... & Subklewe, M. (2021). CD33 BiTE® Construct Mediated Immunological Synapse Formation and Downstream Signaling in T Cells Is Dependent on Expression of Costimulatory Molecules on Target Cells. Blood, 138(Supplement 1), 2237-2237.

Chiu, E., Felices, M., Cichocki, F., Davis, Z., Wang, H., Tuninga, K., ... & Miller, J. S. (2021). Anti-NKG2C/IL-15/anti-CD33 killer engager directs primary and iPSC-derived NKG2C+ NK cells to target myeloid leukemia. Molecular Therapy.

Molica, M., Perrone, S., Mazzone, C., Niscola, P., Cesini, L., Abruzzese, E., & de Fabritiis, P. (2021). CD33 Expression and gentuzumab ozogamicin in acute myeloid leukemia: Two sides of the same coin. Cancers, 13(13), 3214.

Rotiroti, M. C., Buracchi, C., Arcangeli, S., Galimberti, S., Valsecchi, M. G., Perriello, V. M., ... & Tettamanti, S. (2020). Targeting CD33 in chemoresistant AML patient-derived xenografts by CAR-CIK cells modified with an improved SB transposon system. Molecular Therapy, 28(9), 1974-1986.

Griciuc, A., Federico, A. N., Natasan, J., Forte, A. M., McGinty, D., Nguyen, H., ... & Maguire, C. A. (2020). Gene therapy for Alzheimer’s disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation. Human molecular genetics, 29(17), 2920-2935.

Miles, L. A., Hermans, S. J., Crespi, G. A., Gooi, J. H., Doughty, L., Nero, T. L., ... & Parker, M. W. (2019). Small molecule binding to Alzheimer risk factor CD33 promotes Aβ phagocytosis. Iscience, 19, 110-118.

Subklewe, M., Stein, A., Walter, R. B., Bhatia, R., Wei, A. H., Ritchie, D., ... & Ravandi, F. (2019). Preliminary results from a phase 1 first-in-human study of AMG 673, a novel half-life extended (HLE) anti-CD33/CD3 BiTE®(bispecific T-cell engager) in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML).

Westervelt, P., Roboz, G. J., Cortes, J. E., Kantarjian, H. M., Lee, S., Rettig, M. P., ... & DiPersio, J. F. (2018). Phase 1 first-in-human trial of AMV564, a bivalent bispecific (2x2) CD33/CD3 T-cell Engager, in patients with relapsed/refractory acute myeloid leukemia (AML). Blood, 132, 1455.

Son, M., Diamond, B., Volpe, B. T., Aranow, C. B., Mackay, M. C., & Santiago-Schwarz, F. (2017). Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression. Scientific reports, 7(1), 1-13.

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For research use only. Not intended for any clinical use.

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