CD33 Matched Antibody Pair (217) (APMAB-217LY)

Name: CD33 Matched Antibody Pair (217)
SKU: APMAB-217LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-CD33 polyclonal antibody, 100 ug

Detection Antibody

Anti-CD33 Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

CD33 (CD33 Molecule) is a Protein Coding gene. Diseases associated with CD33 include Gallbladder Lymphoma and Extracutaneous Mastocytoma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is SIGLEC6.

Alternative Names

CD33 Molecule; Sialic Acid-Binding Ig-Like Lectin 3; CD33 Antigen (Gp67); SIGLEC-3; SIGLEC3; Gp67;

Entrez Gene ID

945

UniProt ID

P20138

More Infomation

Marcinek, A., Brauchle, B., Hänel, G., Lacher, S. M., Zieger, N., Kischel, R., ... & Subklewe, M. (2021). CD33 BiTE® Construct Mediated Immunological Synapse Formation and Downstream Signaling in T Cells Is Dependent on Expression of Costimulatory Molecules on Target Cells. Blood, 138(Supplement 1), 2237-2237.

Chiu, E., Felices, M., Cichocki, F., Davis, Z., Wang, H., Tuninga, K., ... & Miller, J. S. (2021). Anti-NKG2C/IL-15/anti-CD33 killer engager directs primary and iPSC-derived NKG2C+ NK cells to target myeloid leukemia. Molecular Therapy.

Molica, M., Perrone, S., Mazzone, C., Niscola, P., Cesini, L., Abruzzese, E., & de Fabritiis, P. (2021). CD33 Expression and gentuzumab ozogamicin in acute myeloid leukemia: Two sides of the same coin. Cancers, 13(13), 3214.

Rotiroti, M. C., Buracchi, C., Arcangeli, S., Galimberti, S., Valsecchi, M. G., Perriello, V. M., ... & Tettamanti, S. (2020). Targeting CD33 in chemoresistant AML patient-derived xenografts by CAR-CIK cells modified with an improved SB transposon system. Molecular Therapy, 28(9), 1974-1986.

Griciuc, A., Federico, A. N., Natasan, J., Forte, A. M., McGinty, D., Nguyen, H., ... & Maguire, C. A. (2020). Gene therapy for Alzheimer’s disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation. Human molecular genetics, 29(17), 2920-2935.

Miles, L. A., Hermans, S. J., Crespi, G. A., Gooi, J. H., Doughty, L., Nero, T. L., ... & Parker, M. W. (2019). Small molecule binding to Alzheimer risk factor CD33 promotes Aβ phagocytosis. Iscience, 19, 110-118.

Subklewe, M., Stein, A., Walter, R. B., Bhatia, R., Wei, A. H., Ritchie, D., ... & Ravandi, F. (2019). Preliminary results from a phase 1 first-in-human study of AMG 673, a novel half-life extended (HLE) anti-CD33/CD3 BiTE®(bispecific T-cell engager) in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML).

Westervelt, P., Roboz, G. J., Cortes, J. E., Kantarjian, H. M., Lee, S., Rettig, M. P., ... & DiPersio, J. F. (2018). Phase 1 first-in-human trial of AMV564, a bivalent bispecific (2x2) CD33/CD3 T-cell Engager, in patients with relapsed/refractory acute myeloid leukemia (AML). Blood, 132, 1455.

Son, M., Diamond, B., Volpe, B. T., Aranow, C. B., Mackay, M. C., & Santiago-Schwarz, F. (2017). Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression. Scientific reports, 7(1), 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

CD33 Matched Antibody Pair (218) (CAT#: APMAB-218LY)

CD33 Matched Antibody Pair (219) (CAT#: APMAB-219LY)

Antibody Pairs

CD33 Matched Antibody Pair (218) (CAT#: APMAB-218LY)

CD33 Matched Antibody Pair (219) (CAT#: APMAB-219LY)

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Isotype control

For research use only. Not intended for any clinical use.

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