CDKN1C

CDKN1C (Cyclin Dependent Kinase Inhibitor 1C) is a Protein Coding gene. Diseases associated with CDKN1C include Beckwith-Wiedemann Syndrome and Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies. Among its related pathways are Primary Focal Segmental Glomerulosclerosis FSGS and DNA Damage. Gene Ontology (GO) annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN1B.
Full Name
Cyclin Dependent Kinase Inhibitor 1C
Function
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Biological Process
Cell cycle arrest Source: InterPro
Negative regulation of cyclin-dependent protein kinase activity Source: CAFA
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Negative regulation of epithelial cell proliferation Source: BHF-UCL
Negative regulation of kinase activity Source: UniProtKB
Negative regulation of mitotic cell cycle Source: GO_Central
Negative regulation of phosphorylation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Cellular Location
Nucleus
Involvement in disease
Beckwith-Wiedemann syndrome (BWS): A disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies (IMAGE): A rare condition characterized by intrauterine growth restriction, metaphyseal dysplasia, congenital adrenal hypoplasia, and genital anomalies. Patients with this condition may present shortly after birth with severe adrenal insufficiency, which can be life-threatening if not recognized early and commenced on steroid replacement therapy. Other reported features in this condition include, hypercalciuria and/or hypercalcemia, craniosynostosis, cleft palate, and scoliosis.
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Anti-CDKN1C antibodies

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Rabbit Anti-CDKN1C Recombinant Antibody (C10850) (CBMAB-C10850-LY)

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Target: CDKN1C
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C10850
Application*: P, IF, WB
Datasheet SDS

Mouse Anti-CDKN1C Recombinant Antibody (CBXC-0342) (CBMAB-C5107-CQ)

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Target: CDKN1C
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-0342
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-CDKN1C Recombinant Antibody (CBFYC-1634) (CBMAB-C1694-FY)

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Target: CDKN1C
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1634
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CDKN1C Recombinant Antibody (C2983) (CBMAB-C2983-LY)

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Target: CDKN1C
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: C2983
Application*: P, IF, F
Datasheet SDS

Rabbit Anti-CDKN1C Recombinant Antibody (13B162) (CBMAB-C2796-LY)

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Target: CDKN1C
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 13B162
Application*: P
Datasheet SDS

Mouse Anti-CDKN1C Recombinant Antibody (3F244) (CBMAB-K0279-LY)

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Target: CDKN1C
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 3F244
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-CDKN1C Recombinant Antibody (K0278) (CBMAB-K0278-LY)

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Target: CDKN1C
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: K0278
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-CDKN1C Recombinant Antibody (CBT979) (V2LY-0625-LY3128)

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Target: CDKN1C
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT979
Application*: WB, E
Datasheet SDS

Mouse Anti-CDKN1C Recombinant Antibody (CBT3411) (V2LY-0625-LY2503)

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Target: CDKN1C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3411
Application*: WB
Datasheet SDS

Mouse Anti-CDKN1C Recombinant Antibody (CBT2908) (V2LY-0625-LY1425)

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Target: CDKN1C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2908
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-CDKN1C Recombinant Antibody (CBT4062) (V2LY-0625-LY1424)

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Target: CDKN1C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4062
Application*: WB, IH, IC, F
Datasheet SDS

Rabbit Anti-CDKN1C Recombinant Antibody (EG627) (CBMAB-EN756-LY)

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Target: CDKN1C (Phospho-Thr310)
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG627
Application*: P
Datasheet SDS

Mouse Anti-CDKN1C Monoclonal Antibody (R0027) (CBMAB-R0027-FY)

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Target: CDKN1C
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: R0027
Application*: WB, IP, IF, E, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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