Sign in or Register   Sign in or Register
  |  

Mouse Anti-CDKN1C Recombinant Antibody (3F244) (CBMAB-K0279-LY)

This product is antibody recognizes CDKN1C. The antibody 3F244 immunoassay techniques such as: IP, IHC.
See all CDKN1C antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
3F244
Antibody Isotype
IgG
Application
IP, IHC

Basic Information

Immunogen
Recognizes Kip2, p57.
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cyclin Dependent Kinase Inhibitor 1C
Introduction
CDKN1C (Cyclin Dependent Kinase Inhibitor 1C) is a Protein Coding gene. Diseases associated with CDKN1C include Beckwith-Wiedemann Syndrome and Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies. Among its related pathways are Primary Focal Segmental Glomerulosclerosis FSGS and DNA Damage. Gene Ontology (GO) annotations related to this gene include cyclin-dependent protein serine/threonine kinase inhibitor activity. An important paralog of this gene is CDKN1B.
Entrez Gene ID
Human1028
Mouse12577
UniProt ID
HumanP49918
MouseP49919
Function
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Biological Process
Cell cycle arrest Source: InterPro
Negative regulation of cyclin-dependent protein kinase activity Source: CAFA
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Negative regulation of epithelial cell proliferation Source: BHF-UCL
Negative regulation of kinase activity Source: UniProtKB
Negative regulation of mitotic cell cycle Source: GO_Central
Negative regulation of phosphorylation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Cellular Location
Nucleus
Involvement in disease
Beckwith-Wiedemann syndrome (BWS): A disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies (IMAGE): A rare condition characterized by intrauterine growth restriction, metaphyseal dysplasia, congenital adrenal hypoplasia, and genital anomalies. Patients with this condition may present shortly after birth with severe adrenal insufficiency, which can be life-threatening if not recognized early and commenced on steroid replacement therapy. Other reported features in this condition include, hypercalciuria and/or hypercalcemia, craniosynostosis, cleft palate, and scoliosis.

Yang, D., Feng, W., Zhuang, Y., Liu, J., Feng, Z., Xu, T., ... & Wang, Z. (2021). Long non-coding RNA linc00665 inhibits CDKN1C expression by binding to EZH2 and affects cisplatin sensitivity of NSCLC cells. Molecular Therapy-Nucleic Acids, 23, 1053-1065.

Kagiyama, Y., Fujita, S., Shima, Y., Yamagata, K., Katsumoto, T., Nakagawa, M., ... & Kitabayashi, I. (2021). CDKN1C‐mediated growth inhibition by an EZH1/2 dual inhibitor overcomes resistance of mantle cell lymphoma to ibrutinib. Cancer Science, 112(6), 2314.

Yang, C., Yan, Z., Hu, F., Wei, W., Sun, Z., & Xu, W. (2020). Silencing of microRNA-517a induces oxidative stress injury in melanoma cells via inactivation of the JNK signaling pathway by upregulating CDKN1C. Cancer cell international, 20(1), 1-14.

Na, H., Li, X., Zhang, X., Xu, Y., Sun, Y., Cui, J., ... & Zuo, Y. (2020). lncRNA STEAP3-AS1 Modulates Cell Cycle Progression via Affecting CDKN1C Expression through STEAP3 in Colon Cancer. Molecular Therapy-Nucleic Acids, 21, 480-491.

Wang, Z., Zhu, H., Shi, H., Zhao, H., Gao, R., Weng, X., ... & Ge, J. (2019). Exosomes derived from M1 macrophages aggravate neointimal hyperplasia following carotid artery injuries in mice through miR-222/CDKN1B/CDKN1C pathway. Cell death & disease, 10(6), 1-15.

Lalem, T., Zhang, L., Scholz, M., Burkhardt, R., Saccheti, V., Teren, A., ... & Devaux, Y. (2019). Cyclin dependent kinase inhibitor 1 C is a female-specific marker of left ventricular function after acute myocardial infarction. International journal of cardiology, 274, 319-325.

Qiu, Z., Zhu, W., Meng, H., Tong, L., Li, X., Luo, P., ... & Zhang, J. (2019). CDYL promotes the chemoresistance of small cell lung cancer by regulating H3K27 trimethylation at the CDKN1C promoter. Theranostics, 9(16), 4717.

Suntharalingham, J. P., Ishida, M., Buonocore, F., Del Valle, I., Solanky, N., Demetriou, C., ... & Achermann, J. C. (2019). Analysis of CDKN1C in fetal growth restriction and pregnancy loss. F1000Research, 8.

Lalem, T., Zhang, L., Scholz, M., Burkhardt, R., Saccheti, V., Thiery, J., ... & Cardiolinc™ network (www. cardiolinc. org). (2018). P830 Cyclin dependent kinase inhibitor 1C (CDKN1C), a novel female-specific marker of left ventricular dysfunction after acute myocardial infarction. European Heart Journal, 39(suppl_1), ehy564-P830.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-CDKN1C Recombinant Antibody (3F244)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare