ENO3

This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in skeletal muscle cells in the adult. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene can be associated with metabolic myopathies that may result from decreased stability of the enzyme. Two transcripts have been identified for this gene that differ only in their 5' UTR. [provided by RefSeq]

enolase 3 (beta, muscle)

Appears to have a function in striated muscle development and regeneration.

Aging Source: Ensembl
Glycolytic process Source: GO_Central
Regulation of vacuole fusion, non-autophagic Source: GO_Central
Response to drug Source: Ensembl
Skeletal muscle tissue regeneration Source: Ensembl

Cytoplasm. Localized to the Z line. Some colocalization with CKM at M-band (By similarity).

Glycogen storage disease 13 (GSD13):
A metabolic disorder that results in exercise-induced myalgias, generalized muscle weakness and fatigability. It is characterized by increased serum creatine kinase and decreased enolase 3 activity. Dramatically reduced protein levels with focal sarcoplasmic accumulation of glycogen-beta particles are detected on ultrastructural analysis.