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Mouse Anti-ENO3 (AA 1-434) Recombinant Antibody (CBFYE-0882) (CBMAB-E1346-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0882
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
ENO3 full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: MAMQKIFARE ILDSRGNPTV EVDLHTAKGR FRAAVPSGAS TGIYEALELR DGDKGRYLGK GVLKAVENIN STLGPALLQK KLSVADQEKV DKFMIELDGT ENKSKFGANA ILGVSLAVCK AGAAEKGVPL YRHIADLAGN PDLILPVPAF NVINGGSHAG NKLAMQEFMI LPVGASSFKE AMRIGAEVYH HLKGVIKAKY GKDATNVGDE GGFAPNILEN NEALELLKTA IQAAGYPDKV VIGMDVAASE FYRNGKYDLD FKSPDDPARH ITGEKLGELY KSFIKNYPVV SIEDPFDQDD WATWTSFLSG VNIQIVGDDL TVTNPKRIAQ AVEKKACNCL LLKVNQIGSV TESIQACKLA QSNGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL MRIEEALGDK AIFAGRKFRN PKAK
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-434

Target

Full Name
enolase 3 (beta, muscle)
Introduction
This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.
Entrez Gene ID
2027
UniProt ID
P13929
Alternative Names
Enolase 3; Enolase 3 (Beta, Muscle); Muscle Enriched Enolase; Muscle-Specific Enolase; Skeletal Muscle Enolase; Beta-Enolase; EC 4.2.1.11
Research Area
Appears to have a function in striated muscle development and regeneration.
Biological Process
Aging Source: Ensembl
Glycolytic process Source: GO_Central
Regulation of vacuole fusion, non-autophagic Source: GO_Central
Response to drug Source: Ensembl
Skeletal muscle tissue regeneration Source: Ensembl
Cellular Location
Cytoplasm. Localized to the Z line. Some colocalization with CKM at M-band (By similarity).
Involvement in disease
Glycogen storage disease 13 (GSD13):
A metabolic disorder that results in exercise-induced myalgias, generalized muscle weakness and fatigability. It is characterized by increased serum creatine kinase and decreased enolase 3 activity. Dramatically reduced protein levels with focal sarcoplasmic accumulation of glycogen-beta particles are detected on ultrastructural analysis.
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For research use only. Not intended for any clinical use.

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