GPR75

GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.

G protein-coupled receptor 75

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.

Chemokine-mediated signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: UniProtKB
Regulation of neuron death Source: UniProtKB

Cell membrane

Extracellular: 1-46
Helical: 47-67
Cytoplasmic: 68-86
Helical: 87-107
Extracellular: 108-120
Helical: 121-141
Cytoplasmic: 142-160
Helical: 161-181
Extracellular: 182-205
Helical: 206-226
Cytoplasmic: 227-318
Helical: 319-339
Extracellular: 340-350
Helical: 351-371
Cytoplasmic: 372-540