Mouse Anti-GPR75 Recombinant Antibody (5) (CBMAB-G0721-LY)

Name: Mouse Anti-GPR75 Recombinant Antibody (5)
SKU: CBMAB-G0721-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

Application

IHC

Immunogen

Human GPR75.

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, trehalose

Preservative

None

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

G protein-coupled receptor 75

Introduction

GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]

Entrez Gene ID

10936

UniProt ID

O95800

Alternative Names

G Protein-Coupled Receptor 75; Probable G-Protein Coupled Receptor 75; GPRchr2; WI31133;

Function

G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.

Biological Process

Chemokine-mediated signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: UniProtKB
Regulation of neuron death Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 1-46
Helical: 47-67
Cytoplasmic: 68-86
Helical: 87-107
Extracellular: 108-120
Helical: 121-141
Cytoplasmic: 142-160
Helical: 161-181
Extracellular: 182-205
Helical: 206-226
Cytoplasmic: 227-318
Helical: 319-339
Extracellular: 340-350
Helical: 351-371
Cytoplasmic: 372-540

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-GPR75 Recombinant Antibody (EG1407) (CAT#: V2LY-0226-LY895)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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