IMPDH2

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq]

IMP (inosine monophosphate) dehydrogenase 2

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7903306, PubMed:7763314).
Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016).
It may also have a role in the development of malignancy and the growth progression of some tumors.

de novo' XMP biosynthetic processIEA:Ensembl
Cellular response to interleukin-4IEA:Ensembl
Circadian rhythmManual Assertion Based On ExperimentIDA:UniProtKB
GMP biosynthetic processIEA:UniProtKB-UniRule
GTP biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Lymphocyte proliferationIEA:Ensembl
Retina development in camera-type eyeIEA:Ensembl

Cytoplasm; Nucleus; Cytoplasm, cytosol. Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion.

Ubiquitinated leading to its degradation by the proteasome.
The N-terminus is blocked.
Acetylated by CLOCK in a circadian manner (PubMed:28985504).