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Mouse Anti-IMPDH2 Recombinant Antibody (CBYY-I0805) (CBMAB-I1795-YY)

This product is Mouse antibody that recognizes IMPDH2. The antibody CBYY-I0805 can be used for immunoassay techniques such as: WB
See all IMPDH2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-I0805
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
0.2 μm filtered solution in with Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
IMP (inosine monophosphate) dehydrogenase 2
Introduction
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Entrez Gene ID
Human3615
Mouse23918
Rat301005
UniProt ID
HumanP12268
MouseP24547
RatE9PU28
Alternative Names
Inosine Monophosphate Dehydrogenase 2
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7903306, PubMed:7763314).
Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016).
It may also have a role in the development of malignancy and the growth progression of some tumors.
Biological Process
de novo' XMP biosynthetic processIEA:Ensembl
Cellular response to interleukin-4IEA:Ensembl
Circadian rhythmManual Assertion Based On ExperimentIDA:UniProtKB
GMP biosynthetic processIEA:UniProtKB-UniRule
GTP biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Lymphocyte proliferationIEA:Ensembl
Retina development in camera-type eyeIEA:Ensembl
Cellular Location
Cytoplasm; Nucleus; Cytoplasm, cytosol. Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion.
PTM
Ubiquitinated leading to its degradation by the proteasome.
The N-terminus is blocked.
Acetylated by CLOCK in a circadian manner (PubMed:28985504).

Lin, J., Li, C., Cui, Y., Hou, Y., Zhang, L., Ou, R., ... & Shang, H. (2023). Rare variants in IMPDH2 cause autosomal dominant dystonia in Chinese population. Journal of Neurology, 270(4), 2197-2203.

Wang, S., Chao, F., Zhang, C., Han, D., Xu, G., & Chen, G. (2022). Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer. Cancer letters, 524, 109-120.

Xu, H., Ma, H., Zha, L., Li, Q., Pan, H., & Zhang, L. (2022). Genistein promotes apoptosis of lung cancer cells through the IMPDH2/AKT1 pathway. American journal of translational research, 14(10), 7040.

Wang, W., Wu, Y., Chen, S., Liu, X., He, J., Wang, S., ... & Huang, J. (2021). Shikonin is a novel and selective IMPDH2 inhibitor that target triple‐negative breast cancer. Phytotherapy Research, 35(1), 463-476.

Kuukasjärvi, A., Landoni, J. C., Kaukonen, J., Juhakoski, M., Auranen, M., Torkkeli, T., ... & Suomalainen, A. (2021). IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder. European Journal of Human Genetics, 29(12), 1833-1837.

Kofuji, S., & Sasaki, A. T. (2020). GTP metabolic reprogramming by IMPDH2: unlocking cancer cells’ fuelling mechanism. The journal of biochemistry, 168(4), 319-328.

Johnson, M. C., & Kollman, J. M. (2020). Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, e53243.

Zheng, P., & Li, L. (2020). FANCI cooperates with IMPDH2 to promote lung adenocarcinoma tumor growth via a MEK/ERK/MMPs pathway. OncoTargets and therapy, 451-463.

Hayward, D., Kouznetsova, V. L., Pierson, H. E., Hasan, N. M., Guzman, E. R., Tsigelny, I. F., & Lutsenko, S. (2019). ANKRD9 is a metabolically-controlled regulator of IMPDH2 abundance and macro-assembly. Journal of Biological Chemistry, 294(39), 14454-14466.

Duan, S., Huang, W., Liu, X., Liu, X., Chen, N., Xu, Q., ... & Zhou, J. (2018). IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways. Journal of Experimental & Clinical Cancer Research, 37(1), 1-16.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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