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MUC5AC

MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC5AC include Pseudomyxoma Peritonei and Pancreatic Cancer. Among its related pathways are Metabolism of proteins and CLEC7A (Dectin-1) signaling. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is KCP.
Full Name
Mucin 5AC, Oligomeric Mucus/Gel-Forming
Function
Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370).

Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999).
Biological Process
Phosphatidylinositol-mediated signaling Source: UniProtKB
Cellular Location
Secreted
PTM
C-, O- and N-glycosylated (PubMed:14718370). O-glycosylated on the second and last Thr of the Thr-/Ser-rich tandem repeats TTPSPVPTTSTTSA (PubMed:25939779, PubMed:14718370, PubMed:22186971). One form of glycosylation is also known as Lewis B (LeB) blood group antigen, a tetrasaccharide consisting of N-acetylglucosamine having a fucosyl residue attached (PubMed:14535999). It has a role as an epitope and antigen and functions as a receptor for H.pylori binding and facilitates infection (PubMed:14535999). C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis (PubMed:14718370).
Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.

Anti-MUC5AC antibodies

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Mouse Anti-MUC5AC Recombinant Antibody (CBYJT-1484) (CBMAB-T0515-YJ)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-1484
Application*: WB, IC, P, C, E, IP, IF, F

Mouse Anti-MUC5AC Recombinant Antibody (CBFYM-2814) (CBMAB-M3007-FY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rabbit, Rat, Mouse, Cat, Cattle, Chicken
Clone: CBFYM-2814
Application*: P, C

Mouse Anti-MUC5AC (AA 4944-5030) Recombinant Antibody (CBFYM-2813) (CBMAB-M3006-FY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-2813
Application*: E

Mouse Anti-MUC5AC Recombinant Antibody (CBFYM-2812) (CBMAB-M3005-FY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2812
Application*: E, IC, C, P, IP

Mouse Anti-MUC5AC (AA 351-450) Recombinant Antibody (CBFYM-2811) (CBMAB-M3004-FY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2811
Application*: E, WB

Mouse Anti-MUC5AC Recombinant Antibody (CBFYM-0749) (CBMAB-M0891-FY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0749
Application*: E, IC, IH, IP, WB

Mouse Anti-MUC5AC Recombinant Antibody (CBFYM-0425) (CBMAB-M0539-FY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0425
Application*: F, IF, P

Mouse Anti-MUC5AC Recombinant Antibody (CBFYM-0089) (CBMAB-M0100-FY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0089
Application*: C, P

Mouse Anti-MUC5AC Recombinant Antibody (MUC5AC/917 + 45M1) (CBMAB-M0475-FY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: MUC5AC/917 + 45M1
Application*: F, IF, C

Mouse Anti-MUC5AC Recombinant Antibody (A1252) (CBMAB-AP4928LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1252
Application*: ICC, IHC, IP, WB

Mouse Anti-MUC5AC Recombinant Antibody (A1251) (CBMAB-AP4916LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1251
Application*: FC, IF, IHC

Mouse Anti-MUC5AC Recombinant Antibody (A1250) (CBMAB-AP4912LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cat, Hedgehog, Chicken
Clone: A1250
Application*: FC, IF, IHC

Mouse Anti-MUC5AC Recombinant Antibody (A1249) (CBMAB-AP4918LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1249
Application*: FC, IF, IHC

Mouse Anti-MUC5AC Recombinant Antibody (A1248) (CBMAB-AP4915LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1248
Application*: FC, IF, IHC

Mouse Anti-MUC5AC Recombinant Antibody (A1247) (CBMAB-AP4914LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1247
Application*: FC, IF, IHC

Mouse Anti-MUC5AC Recombinant Antibody (A1246) (CBMAB-AP4913LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1246
Application*: FC, IF, IHC

Mouse Anti-MUC5AC Recombinant Antibody (A1245) (CBMAB-AP4911LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cat, Hedgehog, Chicken
Clone: A1245
Application*: FC, IF, IHC

Mouse Anti-MUC5AC Recombinant Antibody (A1244) (CBMAB-AP4917LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cat, Mouse
Clone: A1244
Application*: FC, IF, IHC

Mouse Anti-MUC5AC Recombinant Antibody (A1243) (CBMAB-AP4908LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cat, Cattle, Chicken
Clone: A1243
Application*: FC, IF, IHC

Mouse Anti-MUC5AC Recombinant Antibody (GM-8A12) (CBMAB-AO756LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GM-8A12
Application*: ELISA, WB, IHC, ICC

Mouse Anti-MUC5AC Recombinant Antibody (MG-31) (CBMAB-AO755LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MG-31
Application*: ELISA, WB, IHC, ICC

Mouse Anti-MUC5AC Monoclonal Antibody (MRQ-19) (CBMAB-R0060-FY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MRQ-19
Application*: ELISA

Mouse Anti-MUC5AC Recombinant Antibody (IHC625) (CBMAB-MA175-YC)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Specificity: Human
Clone: IHC625
Application*: E, IH

Mouse Anti-MUC5AC Recombinant Antibody (2H7) (CBMAB-A5690-LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H7
Application*: WB, E

Mouse Anti-MUC5AC Recombinant Antibody (2A4) (CBMAB-A5689-LY)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2A4
Application*: WB, E

Recombinant Mouse Anti-MUC5AC Recombinant Antibody (Cam 17.1) (CBMAB-XB0851-YC)

Datasheet SDS
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: Cam 17.1
Application*: E, F, IH, IP
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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