MUC5AC
MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC5AC include Pseudomyxoma Peritonei and Pancreatic Cancer. Among its related pathways are Metabolism of proteins and CLEC7A (Dectin-1) signaling. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is KCP.
Full Name
Mucin 5AC, Oligomeric Mucus/Gel-Forming
Function
Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370).
Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999).
Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999).
Biological Process
Phosphatidylinositol-mediated signaling Source: UniProtKB
Cellular Location
Secreted
PTM
C-, O- and N-glycosylated (PubMed:14718370). O-glycosylated on the second and last Thr of the Thr-/Ser-rich tandem repeats TTPSPVPTTSTTSA (PubMed:25939779, PubMed:14718370, PubMed:22186971). One form of glycosylation is also known as Lewis B (LeB) blood group antigen, a tetrasaccharide consisting of N-acetylglucosamine having a fucosyl residue attached (PubMed:14535999). It has a role as an epitope and antigen and functions as a receptor for H.pylori binding and facilitates infection (PubMed:14535999). C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis (PubMed:14718370).
Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.
Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.
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Anti-MUC5AC antibodies
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CompareTarget: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cat, Hedgehog, Chicken
Clone: A1250
Application*: FC, IF, IHC
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MG-31
Application*: ELISA, WB, IHC, ICC
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MRQ-19
Application*: ELISA
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2811
Application*: E, WB
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1252
Application*: ICC, IHC, IP, WB
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1251
Application*: FC, IF, IHC
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1249
Application*: FC, IF, IHC
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1248
Application*: FC, IF, IHC
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1247
Application*: FC, IF, IHC
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1246
Application*: FC, IF, IHC
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GM-8A12
Application*: ELISA, WB, IHC, ICC
Target: MUC5AC
Host: Mouse
Specificity: Human
Clone: IHC625
Application*: E, IH
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H7
Application*: WB, E
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2A4
Application*: WB, E
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: Cam 17.1
Application*: E, F, IH, IP
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-1484
Application*: WB, IC, P, C, E, IP, IF, F
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rabbit, Rat, Mouse, Cat, Cattle, Chicken
Clone: CBFYM-2814
Application*: P, C
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-2813
Application*: E
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2812
Application*: E, IC, C, P, IP
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0749
Application*: E, IC, IH, IP, WB
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0425
Application*: F, IF, P
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0089
Application*: C, P
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: MUC5AC/917 + 45M1
Application*: F, IF, C
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4320
Application*: F
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4617
Application*: IH, F
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT3276
Application*: IH, F
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2111
Application*: IH
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cat, Hedgehog, Chicken
Clone: A1245
Application*: FC, IF, IHC
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cat, Mouse
Clone: A1244
Application*: FC, IF, IHC
Target: MUC5AC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cat, Cattle, Chicken
Clone: A1243
Application*: FC, IF, IHC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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