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Mouse Anti-MUC5AC Recombinant Antibody (MUC5AC/917 + 45M1) (CBMAB-M0475-FY)

This product is mouse antibody that recognizes MUC5AC. The antibody MUC5AC/917 + 45M1 can be used for immunoassay techniques such as: FC, IF, IHC-Fr.
See all MUC5AC antibodies
Published Data
Fig.1 Photomicrographs showing double immunofluorescence staining for fundic gland cells in the gastric biopsy.
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Fig.2 MUC5AC and MUC5B immunostaining of CF and non-CF trachea.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
MUC5AC/917 + 45M1
Antibody Isotype
IgG
Application
FC, IF, IHC-Fr

Basic Information

Immunogen
Mucin 5AC glycoprotein (MUC5AC) is a 641kDa glycoprotein belonging to the superfamily of mucins
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA
Preservative
0.05% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mucin 5AC, Oligomeric Mucus/Gel-Forming
Introduction
MUC5AC is a Protein Coding gene. Diseases associated with MUC5AC include Pseudomyxoma Peritonei and Pancreatic Cancer. Among its related pathways are Metabolism of proteins and CLEC7A signaling. Gene Ontology annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is KCP.
Entrez Gene ID
4586
UniProt ID
P98088
Alternative Names
Mucin 5AC, Oligomeric Mucus/Gel-Forming; Mucin 5, Subtypes A And C, Tracheobronchial/Gastric; Mucin-5 Subtype AC, Tracheobronchial; Lewis B Blood Group Antigen; Major Airway Glycoprotein; Tracheobronchial Mucin; Gastric Mucin; MUC5
Function
Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370).

Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999).
Biological Process
Phosphatidylinositol-mediated signaling Source: UniProtKB
Cellular Location
Secreted
PTM
C-, O- and N-glycosylated (PubMed:14718370). O-glycosylated on the second and last Thr of the Thr-/Ser-rich tandem repeats TTPSPVPTTSTTSA (PubMed:25939779, PubMed:14718370, PubMed:22186971). One form of glycosylation is also known as Lewis B (LeB) blood group antigen, a tetrasaccharide consisting of N-acetylglucosamine having a fucosyl residue attached (PubMed:14535999). It has a role as an epitope and antigen and functions as a receptor for H.pylori binding and facilitates infection (PubMed:14535999). C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis (PubMed:14718370).
Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.

Song, D., Iverson, E., Kaler, L., Boboltz, A., Scull, M. A., & Duncan, G. A. (2022). MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium. Science Advances, 8(47), eabq5049.

Tajiri, T., Matsumoto, H., Jinnai, M., Kanemitsu, Y., Nagasaki, T., Iwata, T., ... & Niimi, A. (2022). Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma. Allergology International, 71(2), 193-199.

Rico, S. D., Mahnken, M., Büscheck, F., Dum, D., Luebke, A. M., Kluth, M., ... & Marx, A. H. (2021). MUC5AC expression in various tumor types and nonneoplastic tissue: a tissue microarray study on 10 399 tissue samples. Technology in Cancer Research & Treatment, 20, 15330338211043328.

Carpenter, J., Wang, Y., Gupta, R., Li, Y., Haridass, P., Subramani, D. B., ... & Kesimer, M. (2021). Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B. Proceedings of the National Academy of Sciences, 118(39), e2104490118.

Radicioni, G., Ceppe, A., Ford, A. A., Alexis, N. E., Barr, R. G., Bleecker, E. R., ... & Kesimer, M. (2021). Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort. The Lancet Respiratory Medicine, 9(11), 1241-1254.

Manne, A., Esnakula, A., Abushahin, L., & Tsung, A. (2021). Understanding the clinical impact of MUC5AC expression on pancreatic ductal adenocarcinoma. Cancers, 13(12), 3059.

Li, J., & Ye, Z. (2020). The potential role and regulatory mechanisms of MUC5AC in chronic obstructive pulmonary disease. Molecules, 25(19), 4437.

Olli, K. E., Rapp, C., O’Connell, L., Collins, C. B., McNamee, E. N., Jensen, O., ... & Aherne, C. M. (2020). Muc5ac expression protects the colonic barrier in experimental colitis. Inflammatory bowel diseases, 26(9), 1353-1367.

Samsuzzaman, M., Uddin, M. S., Shah, M. A., & Mathew, B. (2019). Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production. Life sciences, 231, 116485.

Okuda, K., Chen, G., Subramani, D. B., Wolf, M., Gilmore, R. C., Kato, T., ... & Boucher, R. C. (2019). Localization of secretory mucins MUC5AC and MUC5B in normal/healthy human airways. American journal of respiratory and critical care medicine, 199(6), 715-727.

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For research use only. Not intended for any clinical use.

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