Mouse Anti-MUC5AC Recombinant Antibody (CBFYM-0089) (CBMAB-M0100-FY)

Name: Mouse Anti-MUC5AC Recombinant Antibody (CBFYM-0089)
SKU: CBMAB-M0100-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0089

Application

IHC-Fr, IHC-P

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.05% Sodium azide

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Mucin 5AC, Oligomeric Mucus/Gel-Forming

Introduction

MUC5AC is a Protein Coding gene. Diseases associated with MUC5AC include Pseudomyxoma Peritonei and Pancreatic Cancer. Among its related pathways are Metabolism of proteins and CLEC7A signaling. Gene Ontology annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is KCP.

Entrez Gene ID

4586

UniProt ID

P98088

Alternative Names

Mucin 5AC, Oligomeric Mucus/Gel-Forming; Mucin 5, Subtypes A And C, Tracheobronchial/Gastric; Mucin-5 Subtype AC, Tracheobronchial; Lewis B Blood Group Antigen; Major Airway Glycoprotein; Tracheobronchial Mucin; Gastric Mucin; MUC5

Function

Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370).

Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999).

Biological Process

Phosphatidylinositol-mediated signaling Source: UniProtKB

Cellular Location

Secreted

PTM

C-, O- and N-glycosylated (PubMed:14718370). O-glycosylated on the second and last Thr of the Thr-/Ser-rich tandem repeats TTPSPVPTTSTTSA (PubMed:25939779, PubMed:14718370, PubMed:22186971). One form of glycosylation is also known as Lewis B (LeB) blood group antigen, a tetrasaccharide consisting of N-acetylglucosamine having a fucosyl residue attached (PubMed:14535999). It has a role as an epitope and antigen and functions as a receptor for H.pylori binding and facilitates infection (PubMed:14535999). C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis (PubMed:14718370).
Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.

Song, D., Iverson, E., Kaler, L., Boboltz, A., Scull, M. A., & Duncan, G. A. (2022). MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium. Science Advances, 8(47), eabq5049.

Tajiri, T., Matsumoto, H., Jinnai, M., Kanemitsu, Y., Nagasaki, T., Iwata, T., ... & Niimi, A. (2022). Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma. Allergology International, 71(2), 193-199.

Rico, S. D., Mahnken, M., Büscheck, F., Dum, D., Luebke, A. M., Kluth, M., ... & Marx, A. H. (2021). MUC5AC expression in various tumor types and nonneoplastic tissue: a tissue microarray study on 10 399 tissue samples. Technology in Cancer Research & Treatment, 20, 15330338211043328.

Carpenter, J., Wang, Y., Gupta, R., Li, Y., Haridass, P., Subramani, D. B., ... & Kesimer, M. (2021). Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B. Proceedings of the National Academy of Sciences, 118(39), e2104490118.

Radicioni, G., Ceppe, A., Ford, A. A., Alexis, N. E., Barr, R. G., Bleecker, E. R., ... & Kesimer, M. (2021). Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort. The Lancet Respiratory Medicine, 9(11), 1241-1254.

Manne, A., Esnakula, A., Abushahin, L., & Tsung, A. (2021). Understanding the clinical impact of MUC5AC expression on pancreatic ductal adenocarcinoma. Cancers, 13(12), 3059.

Li, J., & Ye, Z. (2020). The potential role and regulatory mechanisms of MUC5AC in chronic obstructive pulmonary disease. Molecules, 25(19), 4437.

Olli, K. E., Rapp, C., O’Connell, L., Collins, C. B., McNamee, E. N., Jensen, O., ... & Aherne, C. M. (2020). Muc5ac expression protects the colonic barrier in experimental colitis. Inflammatory bowel diseases, 26(9), 1353-1367.

Samsuzzaman, M., Uddin, M. S., Shah, M. A., & Mathew, B. (2019). Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production. Life sciences, 231, 116485.

Okuda, K., Chen, G., Subramani, D. B., Wolf, M., Gilmore, R. C., Kato, T., ... & Boucher, R. C. (2019). Localization of secretory mucins MUC5AC and MUC5B in normal/healthy human airways. American journal of respiratory and critical care medicine, 199(6), 715-727.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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