TJP2

Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton.[supplied by OMIM

Full Name

tight junction protein 2 (zona occludens 2)

Function

Plays a role in tight junctions and adherens junctions.

Biological Process

Biological Process cell-cell adhesionSource:GO_Central1 Publication
Biological Process cell-cell junction organizationSource:GO_Central1 Publication
Biological Process establishment of endothelial intestinal barrierSource:UniProtKB1 Publication
Biological Process homotypic cell-cell adhesionSource:ARUK-UCL1 Publication
Biological Process intestinal absorptionSource:UniProtKB1 Publication
Biological Process maintenance of blood-brain barrierSource:ARUK-UCL1 Publication
Biological Process positive regulation of blood-brain barrier permeabilitySource:ARUK-UCL1 Publication
Biological Process protein localization to cell-cell junctionSource:GO_Central1 Publication
Biological Process regulation of membrane permeabilitySource:UniProtKB1 Publication

Cellular Location

Cell junction, adherens junction
Cell membrane
Cell junction, tight junction
Nucleus
Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.

Involvement in disease

Hypercholanemia, familial, 1 (FHCA1):
A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.
Cholestasis, progressive familial intrahepatic, 4 (PFIC4):
A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood. PFIC4 inheritance is autosomal recessive.