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Mouse Anti-TJP2 Recombinant Antibody (4D12) (CBMAB-A9117-LY)

The product is antibody recognizes TJP2. The antibody 4D12 immunoassay techniques such as: WB, ELISA.
See all TJP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4D12
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
TJP2 (NP_004808, 121 a.a. ~ 218 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
tight junction protein 2 (zona occludens 2)
Introduction
Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton.[supplied by OMIM
Entrez Gene ID
9414
UniProt ID
Q9UDY2
Alternative Names
MGC26306; X104; ZO-2; ZO2
Function
Plays a role in tight junctions and adherens junctions.
Biological Process
Biological Process cell-cell adhesionSource:GO_Central1 Publication
Biological Process cell-cell junction organizationSource:GO_Central1 Publication
Biological Process establishment of endothelial intestinal barrierSource:UniProtKB1 Publication
Biological Process homotypic cell-cell adhesionSource:ARUK-UCL1 Publication
Biological Process intestinal absorptionSource:UniProtKB1 Publication
Biological Process maintenance of blood-brain barrierSource:ARUK-UCL1 Publication
Biological Process positive regulation of blood-brain barrier permeabilitySource:ARUK-UCL1 Publication
Biological Process protein localization to cell-cell junctionSource:GO_Central1 Publication
Biological Process regulation of membrane permeabilitySource:UniProtKB1 Publication
Cellular Location
Cell junction, adherens junction
Cell membrane
Cell junction, tight junction
Nucleus
Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.
Involvement in disease
Hypercholanemia, familial, 1 (FHCA1):
A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.
Cholestasis, progressive familial intrahepatic, 4 (PFIC4):
A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood. PFIC4 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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