Human TJP2 ELISA Kit (V2LY-0626-LY5330)

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Tested Data
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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0033 ng/mL
Detection Range
0.007-1.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
134.0 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
tight junction protein 2 (zona occludens 2)
Function
Plays a role in tight junctions and adherens junctions.
Biological Process
Biological Process cell-cell adhesionSource:GO_Central1 Publication
Biological Process cell-cell junction organizationSource:GO_Central1 Publication
Biological Process establishment of endothelial intestinal barrierSource:UniProtKB1 Publication
Biological Process homotypic cell-cell adhesionSource:ARUK-UCL1 Publication
Biological Process intestinal absorptionSource:UniProtKB1 Publication
Biological Process maintenance of blood-brain barrierSource:ARUK-UCL1 Publication
Biological Process positive regulation of blood-brain barrier permeabilitySource:ARUK-UCL1 Publication
Biological Process protein localization to cell-cell junctionSource:GO_Central1 Publication
Biological Process regulation of membrane permeabilitySource:UniProtKB1 Publication
Cellular Location
Cell junction, adherens junction
Cell membrane
Cell junction, tight junction
Nucleus
Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.
Involvement in disease
Hypercholanemia, familial, 1 (FHCA1):
A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.
Cholestasis, progressive familial intrahepatic, 4 (PFIC4):
A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood. PFIC4 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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