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Mouse Anti-TJP2 Recombinant Antibody (CBWJZ-273) (CBMAB-Z0710-WJ)

This product is a mouse antibody that recognizes TJP2. The antibody CBWJZ-273 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all TJP2 antibodies

Summary

Host Animal
Mouse
Specificity
Dog, Human
Clone
CBWJZ-273
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Dog, Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL

Target

Full Name
tight junction protein 2 (zona occludens 2)
Introduction
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
Human9414
Dog403854
UniProt ID
HumanQ9UDY2
DogQ95168
Alternative Names
ZO2; X104; PFIC4; DFNA51; DUP9q21.11; C9DUPq21.11
Function
Plays a role in tight junctions and adherens junctions.
Biological Process
Biological Process cell-cell adhesionSource:GO_Central1 Publication
Biological Process cell-cell junction organizationSource:GO_Central1 Publication
Biological Process establishment of endothelial intestinal barrierSource:UniProtKB1 Publication
Biological Process homotypic cell-cell adhesionSource:ARUK-UCL1 Publication
Biological Process intestinal absorptionSource:UniProtKB1 Publication
Biological Process maintenance of blood-brain barrierSource:ARUK-UCL1 Publication
Biological Process positive regulation of blood-brain barrier permeabilitySource:ARUK-UCL1 Publication
Biological Process protein localization to cell-cell junctionSource:GO_Central1 Publication
Biological Process regulation of membrane permeabilitySource:UniProtKB1 Publication
Cellular Location
Cell junction, adherens junction
Cell membrane
Cell junction, tight junction
Nucleus
Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.
Involvement in disease
Hypercholanemia, familial, 1 (FHCA1):
A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.
Cholestasis, progressive familial intrahepatic, 4 (PFIC4):
A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood. PFIC4 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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