TRIB1

TRIB1 (Tribbles Pseudokinase 1) is a Protein Coding gene. Diseases related to TRIB1 include Megakaryocytic Leukemia and Leukemia, Acute Myeloid. Gene Ontology (GO) annotations related to TRIB1 include transferase activity, transferring phosphorus-containing groups and transcription factor binding. An important paralog of TRIB1 is TRIB2.

tribbles homolog 1 (Drosophila)

Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596).
The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797).
Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596).
Binds selectively the recognition sequence of CEBPA (PubMed:26455797).
Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity).
Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity).
Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).

Biological Process JNK cascade Source:BHF-UCL1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCL1 Publication
Biological Process negative regulation of lipopolysaccharide-mediated signaling pathway Source:BHF-UCL1 Publication
Biological Process negative regulation of neutrophil differentiation Source:Ensembl
Biological Process negative regulation of protein kinase activity Source:BHF-UCL1 Publication
Biological Process negative regulation of smooth muscle cell migration Source:BHF-UCL1 Publication
Biological Process negative regulation of smooth muscle cell proliferation Source:BHF-UCL1 Publication
Biological Process positive regulation of eosinophil differentiation Source:Ensembl
Biological Process positive regulation of macrophage differentiation Source:Ensembl
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source:BHF-UCLBy Similarity
Biological Process regulation of MAP kinase activity Source:UniProtKB1 Publication
Biological Process response to lipopolysaccharide Source:BHF-UCL1 Publication

cytoplasm
cytosol
nucleus