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Mouse Anti-TRIB1 Recombinant Antibody (CBYJT-4645) (CBMAB-T4179-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIB1 (Tribbles Pseudokinase 1). The antibody can be used for immunoassay techniques, such as WB.
See all TRIB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4645
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human TRIB1 (NP_079471) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tribbles homolog 1 (Drosophila)
Introduction
TRIB1 (Tribbles Pseudokinase 1) is a Protein Coding gene. Diseases related to TRIB1 include Megakaryocytic Leukemia and Leukemia, Acute Myeloid. Gene Ontology (GO) annotations related to TRIB1 include transferase activity, transferring phosphorus-containing groups and transcription factor binding. An important paralog of TRIB1 is TRIB2.
Entrez Gene ID
10221
UniProt ID
Q96RU8
Alternative Names
Tribbles Pseudokinase 1; G-Protein-Coupled Receptor-Induced Gene 2 Protein; SKIP1; GIG-2; TRB-1; TRB1; C8FW; GIG2
Function
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596).
The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797).
Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596).
Binds selectively the recognition sequence of CEBPA (PubMed:26455797).
Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity).
Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity).
Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).
Biological Process
Biological Process JNK cascade Source:BHF-UCL1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCL1 Publication
Biological Process negative regulation of lipopolysaccharide-mediated signaling pathway Source:BHF-UCL1 Publication
Biological Process negative regulation of neutrophil differentiation Source:Ensembl
Biological Process negative regulation of protein kinase activity Source:BHF-UCL1 Publication
Biological Process negative regulation of smooth muscle cell migration Source:BHF-UCL1 Publication
Biological Process negative regulation of smooth muscle cell proliferation Source:BHF-UCL1 Publication
Biological Process positive regulation of eosinophil differentiation Source:Ensembl
Biological Process positive regulation of macrophage differentiation Source:Ensembl
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source:BHF-UCLBy Similarity
Biological Process regulation of MAP kinase activity Source:UniProtKB1 Publication
Biological Process response to lipopolysaccharide Source:BHF-UCL1 Publication
Cellular Location
cytoplasm
cytosol
nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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