TUB

TUB is a member of the Tubby family of bipartite transcription factors. TUB may function in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it plays a role as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis.

Tubby Bipartite Transcription Factor

Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity).
Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.

Biological Process intraciliary transport Source:MGI1 Publication
Biological Process phagocytosis, recognition Source:Ensembl
Biological Process photoreceptor cell maintenance Source:Ensembl
Biological Process positive regulation of phagocytosis Source:UniProtKB1 Publication
Biological Process protein localization to cilium Source:GO_Central1 Publication
Biological Process protein localization to photoreceptor outer segment Source:Ensembl
Biological Process receptor localization to non-motile cilium Source:Ensembl
Biological Process regulation of G protein-coupled receptor signaling pathway Source:Ensembl
Biological Process response to stimulus Source:UniProtKB-KW
Biological Process retina development in camera-type eye Source:Ensembl
Biological Process sensory perception of sound Source:Ensembl

Cytoplasm
Nucleus
Secreted
Cell membrane
Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity).

Retinal dystrophy and obesity (RDOB):
A disease characterized by obesity, night blindness, decreased visual acuity, and electrophysiological features of a rod cone dystrophy.