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Rabbit Anti-TUB Monoclonal Antibody (EPR8241) (CBMAB-1669-YC)

Provided herein is a rabbit monoclonal antibody against Human TUB. The antibody, clone EPR8241, can be used for immunoassay techniques, such as ICC, IF, IHC-P, FC and WB.
See all TUB antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR8241
Antibody Isotype
IgG
Application
ICC, IF, IHC-P, FC, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues near the N-terminus of Human TUB 1 (UniProt P50607).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tubby Bipartite Transcription Factor
Introduction
TUB is a member of the Tubby family of bipartite transcription factors which may play a role in obesity and sensorineural degradation. TUB functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis.
Entrez Gene ID
Human7275
Mouse22141
Rat25609
UniProt ID
HumanP50607
MouseP50586
RatO88808
Alternative Names
tubby protein homolog; tubby homolog
Function
Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity).
Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
Biological Process
Biological Process intraciliary transport Source:MGI1 Publication
Biological Process phagocytosis, recognition Source:Ensembl
Biological Process photoreceptor cell maintenance Source:Ensembl
Biological Process positive regulation of phagocytosis Source:UniProtKB1 Publication
Biological Process protein localization to cilium Source:GO_Central1 Publication
Biological Process protein localization to photoreceptor outer segment Source:Ensembl
Biological Process receptor localization to non-motile cilium Source:Ensembl
Biological Process regulation of G protein-coupled receptor signaling pathway Source:Ensembl
Biological Process response to stimulus Source:UniProtKB-KW
Biological Process retina development in camera-type eye Source:Ensembl
Biological Process sensory perception of sound Source:Ensembl
Cellular Location
Cytoplasm
Nucleus
Secreted
Cell membrane
Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity).
Involvement in disease
Retinal dystrophy and obesity (RDOB):
A disease characterized by obesity, night blindness, decreased visual acuity, and electrophysiological features of a rod cone dystrophy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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