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C1S

This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency.
Full Name
complement C1s
Function
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
Biological Process
Complement activation Source: Reactome
Complement activation, classical pathway Source: Reactome
Innate immune response Source: UniProtKB-KW
Regulation of complement activation Source: Reactome
Cellular Location
Blood microparticle; Extracellular region; Extracellular space
Involvement in disease
Complement component C1s deficiency (C1SD): A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
Ehlers-Danlos syndrome, periodontal type, 2 (EDSPD2):A form of Ehlers-Danlos syndrome, a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDSPD2 is characterized by the association of typical features of Ehlers-Danlos syndrome with gingival recession and severe early-onset periodontal disease, leading to premature loss of permanent teeth. EDSPD2 transmission pattern is consistent with autosomal dominant inheritance.
PTM
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

Anti-C1S antibodies

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Rabbit Anti-C1S Recombinant Antibody (CBFYC-0612) (CBMAB-C0666-FY)

Datasheet SDS
Target: C1S
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0612
Application*: E

Mouse Anti-C1S Recombinant Antibody (CBFYC-0611) (CBMAB-C0665-FY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBFYC-0611
Application*: WB, P

Mouse Anti-C1S Recombinant Antibody (CBFYA-0121) (CBMAB-X0178-FY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYA-0121
Application*: F, C, FN, IA, IP, P, WB

Mouse Anti-C1S Recombinant Antibody (CBFYA-0120) (CBMAB-X0177-FY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0120
Application*: F, C, FN, IA, IP, P, WB

Mouse Anti-C1S Recombinant Antibody (CBXC-2047) (CBMAB-C3320-CQ)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2047
Application*: WB, IH

Mouse Anti-C1S Recombinant Antibody (CBXC-2234) (CBMAB-C3319-CQ)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2234
Application*: WB, IH, IF, F

Mouse Anti-C1S Recombinant Antibody (CBXC-2011) (CBMAB-C3318-CQ)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2011
Application*: WB, IH

Mouse Anti-C1S Recombinant Antibody (CBXC-1084) (CBMAB-C1350-CQ)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1084
Application*: WB, IP

Mouse Anti-C1S Recombinant Antibody (9) (CBMAB-C9295-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9
Application*: E

Rabbit Anti-C1S Recombinant Antibody (6) (CBMAB-C7834-LY)

Datasheet SDS
Target: C1S
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 6
Application*: E

Mouse Anti-C1S Recombinant Antibody (5F2) (CBMAB-C7563-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5F2
Application*: IF, F, C, WB

Mouse Anti-C1S Recombinant Antibody (4E3) (CBMAB-C6860-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4E3
Application*: WB, P, F, IC/IF

Mouse Anti-C1S Recombinant Antibody (49) (CBMAB-C1351-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 49
Application*: E

Rabbit Anti-C1S Recombinant Antibody (006) (CBMAB-C1529-LY)

Datasheet SDS
Target: C1S
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 006
Application*: E

Mouse Anti-C1S Recombinant Antibody (02) (CBMAB-C1649-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 02
Application*: EC

Mouse Anti-C1S Recombinant Antibody (04) (CBMAB-C1737-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 04
Application*: ED

Mouse Anti-C1S Recombinant Antibody (1G1) (CBMAB-C4106-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G1
Application*: P, WB

Mouse Anti-C1S Recombinant Antibody (2A8) (CBMAB-C4633-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Monkey
Clone: 2A8
Application*: WB, P

Mouse Anti-C1S Recombinant Antibody (2D11) (CBMAB-C4855-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2D11
Application*: WB, P, F

Mouse Anti-C1S Recombinant Antibody (2F5) (CBMAB-C5100-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F5
Application*: C, WB

Mouse Anti-C1S Recombinant Antibody (306904) (CBMAB-C5462-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 306904
Application*: IP, WB

Mouse Anti-C1S Recombinant Antibody (3B11) (CBMAB-C5685-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B11
Application*: WB

Mouse Anti-C1S Recombinant Antibody (4D9) (CBMAB-C6815-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Dog, Human, Monkey
Clone: 4D9
Application*: WB

Mouse Anti-C1S Recombinant Antibody (CBYY-C0798) (CBMAB-C2234-YY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0798
Application*: WB, P, F, IF

Mouse Anti-C1S Recombinant Antibody (CBYY-C0799) (CBMAB-C2235-YY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0799
Application*: IF, F, IH, WB

Rabbit Anti-C1S Recombinant Antibody (CBYY-C0800) (CBMAB-C2236-YY)

Datasheet SDS
Target: C1S
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C0800
Application*: E

Mouse Anti-C1S Recombinant Antibody (CBYY-C2990) (CBMAB-C4433-YY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: CBYY-C2990
Application*: WB, F, IH, IF, P

Mouse Anti-C1S Recombinant Antibody (CBYY-C3034) (CBMAB-C4477-YY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C3034
Application*: F, IF, P, WB

Mouse Anti-C1S Recombinant Antibody (CBYY-C3212) (CBMAB-C4655-YY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C3212
Application*: E

Mouse Anti-C1S Recombinant Antibody (CBXC-2819) (CBMAB-C3317-CQ)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2819
Application*: WB

Mouse Anti-C1S Recombinant Antibody (6F44) (CBMAB-C1124-CN)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6F44
Application*: E

Mouse Anti-C1S Recombinant Antibody (M241) (CBMAB-C1125-CN)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: M241
Application*: WB, IP, E, FN, P, IH

Mouse Anti-C1S Recombinant Antibody (M81) (CBMAB-C1126-CN)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M81
Application*: WB, IP, E, FN, P, IH

Mouse Anti-C1S Recombinant Antibody (CBCNC-127) (CBMAB-C1127-CN)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-127
Application*: FC, C, P, IP, WB

Mouse Anti-C1S Recombinant Antibody (CBCNC-128) (CBMAB-C1128-CN)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBCNC-128
Application*: FC, C, P, IP, WB

Mouse Anti-C1S Recombinant Antibody (CBLC019-LY) (CBMAB-C9527-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLC019-LY
Application*: IA, C, P, IP, WB, FN

Recombinant Mouse Anti-C1s Antibody (CBHb190) (CBMAB-Hb092-LY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb190
Application*: FC, IHC-F, FuncS, Immuno assays, IP, IHC-P, WB

Rabbit Anti-C1S Recombinant Antibody (EG437) (CBMAB-EN496-LY)

Datasheet SDS
Target: C1S
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG437
Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Mouse Anti-C1S Recombinant Antibody (CBYY-C3125) (CBMAB-C4568-YY)

Datasheet SDS
Target: C1S
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C3125
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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