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CD47

CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity.

Full Name

CD47 Molecule

Function

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity).
Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

Biological Process

ATP export Source: ARUK-UCL
Cell migration Source: ARUK-UCL
Cellular response to interferon-gamma Source: ARUK-UCL
Cellular response to interleukin-1 Source: ARUK-UCL
Cellular response to interleukin-12 Source: ARUK-UCL
Extracellular matrix organization Source: Reactome
Integrin-mediated signaling pathway Source: ProtInc
Leukocyte migration Source: Reactome
Monocyte extravasation Source: ARUK-UCL
Negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Source: ARUK-UCL
Neutrophil degranulation Source: Reactome
Positive regulation of cell-cell adhesion Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of inflammatory response Source: GO_Central
Positive regulation of phagocytosis Source: GO_Central
Positive regulation of stress fiber assembly Source: ARUK-UCL
Positive regulation of T cell activation Source: UniProtKB
Regulation of interferon-gamma production Source: ARUK-UCL
Regulation of interleukin-10 production Source: ARUK-UCL
Regulation of interleukin-12 production Source: ARUK-UCL
Regulation of interleukin-6 production Source: ARUK-UCL
Regulation of nitric oxide biosynthetic process Source: ARUK-UCL
Regulation of tumor necrosis factor production Source: ARUK-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 19-141
Helical: 142-162
Cytoplasmic: 163-176
Helical: 177-197
Extracellular: 198-207
Helical: 208-228
Cytoplasmic: 229-235
Helical: 236-256
Extracellular: 257-268
Helical: 269-289
Cytoplasmic: 290-323

Anti-CD47 antibodies

Mouse Anti-CD47 Recombinant Antibody (A065) (CBMAB-AP10843LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: A065

Application*: FC

Mouse Anti-CD47 Recombinant Antibody (A064) (CBMAB-AP10699LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: A064

Application*: FC

Mouse Anti-CD47 Recombinant Antibody (A063) (CBMAB-AP11402LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: A063

Application*: FC, IP, WB

Mouse Anti-CD47 Recombinant Antibody (888) (CBMAB-AP1142LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 888

Application*: ELISA, WB

Mouse Anti-CD47 Recombinant Antibody (BRIC125) (CBMAB-AP1141LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: BRIC125

Application*: ELISA, WB

Mouse Anti-CD47 Recombinant Antibody (CBXC-2506) (CBMAB-C5312-CQ)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-2506

Application*: E, WB

Mouse Anti-CD47 Recombinant Antibody (CBXC-0223) (CBMAB-C5310-CQ)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-0223

Application*: F, IH, IP

Mouse Anti-CD47 Recombinant Antibody (CBXC-0224) (CBMAB-C3217-CQ)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXC-0224

Application*: F, IF, IP

Human Anti-CD47 Recombinant Antibody (CBXC-0753) (CBMAB-C1867-CQ)

SDS

Target: CD47

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0753

Application*: F

Mouse Anti-CD47 Recombinant Antibody (CBXC-1207) (CBMAB-C1474-CQ)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-1207

Application*: F

Mouse Anti-CD47 Recombinant Antibody (MEM-122) (CBMAB-C0862-CQ)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgM

Specificity: Human, Pig, Monkey

Clone: MEM-122

Application*: WB, F, IH, C

Mouse Anti-CD47 Recombinant Antibody (IAP/964) (CBMAB-C0728-CQ)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: IAP/964

Application*: F, P, IF

Mouse Anti-CD47 Recombinant Antibody (B6H12.2) (CBMAB-C0419-CQ)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: B6H12.2

Application*: WB, F, IH, IP, P, MC

Rabbit Anti-CD47 Recombinant Antibody (CBFYC-1335) (CBMAB-C1393-FY)

SDS

Target: CD47

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-1335

Application*: E

Mouse Anti-CD47 Recombinant Antibody (CBFYC-1334) (CBMAB-C1392-FY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Rat

Clone: CBFYC-1334

Application*: E

Mouse Anti-CD47 Recombinant Antibody (CBFYC-1333) (CBMAB-C1391-FY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-1333

Application*: F, C, IP, FN

Mouse Anti- CD47 Recombinant Antibody (B6.H12) (CBMAB-0927-LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: B6.H12

Application*: N, F

Mouse Anti-CD47 Recombinant Antibody (CB108) (CBMAB-CS108LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CB108

Application*: IF, FC

Mouse Anti-CD47 Recombinant Antibody (CB107) (CBMAB-CS107LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CB107

Application*: IF, FC

Mouse Anti-CD47 Recombinant Antibody (CB106) (CBMAB-CS106LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CB106

Application*: IF, FC

Rabbit Anti-CD47 Recombinant Antibody (D3O7P) (CBMAB-CP0214-LY)

SDS

Target: CD47

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D3O7P

Application*: WB, IH, P

Mouse Anti-CD47 Recombinant Antibody (OX101) (CBMAB-C10440-LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: OX101

Application*: IP, WB, F

Mouse Anti-CD47 Recombinant Antibody (C5/D5) (CBMAB-C1822-CN)

SDS

Target: CD47

Host: Mouse

Specificity: Human

Clone: C5/D5

Application*: FC

Mouse Anti-CD47 Recombinant Antibody (3F95) (CBMAB-C0152-CN)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3F95

Application*: FC, IF, IP

Mouse Anti-CD47 Recombinant Antibody (CBYY-C1472) (CBMAB-C2910-YY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Rat

Clone: CBYY-C1472

Application*: E

Mouse Anti-CD47 Recombinant Antibody (CBYY-C1470) (CBMAB-C2908-YY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBYY-C1470

Application*: F, IP, WB

Mouse Anti-CD47 Recombinant Antibody (8J217) (CBMAB-C9257-LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: 8J217

Application*: F, C, WB

Mouse Anti-CD47 Recombinant Antibody (8) (CBMAB-C8889-LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Rat

Clone: 8

Application*: E

Mouse Anti-CD47 Recombinant Antibody (6A296) (CBMAB-C8002-LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: 6A296

Application*: WB, P, F

Mouse Anti-CD47 Recombinant Antibody (3H1456) (CBMAB-C6244-LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Cattle, Dog, Pig, Sheep

Clone: 3H1456

Application*: F, IH, IP

Rabbit Anti-CD47 Recombinant Antibody (1) (CBMAB-C1913-LY)

SDS

Target: CD47

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 1

Application*: E

Mouse Anti-CD47 Recombinant Antibody (472603) (CBMAB-C1334-LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 472603

Application*: F, MC

Mouse Anti-CD47 Recombinant Antibody (3H1457) (CBMAB-C1175-LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: 3H1457

Application*: F, IP

Mouse Anti-CD47 Recombinant Antibody (2D3) (CBMAB-C0861-LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2D3

Application*: C, WB

Mouse Anti-CD47 Recombinant Antibody (10B1691) (CBMAB-C0145-LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 10B1691

Application*: F, IH, IP

Mouse Anti-CD47 Recombinant Antibody (1/1A4) (CBMAB-C0113-LY)

SDS

Target: CD47

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1/1A4

Application*: C, P, F

Rat Anti-CD47 Recombinant Antibody (MIAP301) (CBMAB-0991-LY)

SDS

Target: CD47 (IAP)

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: MIAP301

Application*: B, IF

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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