CD6
CD6 (CD6 Molecule) is a Protein Coding gene. Diseases associated with CD6 include Bronchus Cancer and Inflammatory Bowel Disease 16. Among its related pathways are Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is LOXL4.
Function
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089).
Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089).
Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752).
Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806).
Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777).
LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777).
Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).
Biological Process
Acute inflammatory response to antigenic stimulus Source: UniProtKB
Adaptive immune response Source: UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Immunological synapse formation Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Lipopolysaccharide-mediated signaling pathway Source: UniProtKB
Positive regulation of cytokine production involved in inflammatory response Source: UniProtKB
Positive regulation of T cell proliferation Source: UniProtKB
Response to lipopolysaccharide Source: UniProtKB
Cellular Location
Cell membrane. Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938).
Soluble CD6: Secreted. The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain.
Topology
Extracellular: 18-402
Helical: 403-423
Cytoplasmic: 424-668
PTM
After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.
Glycosylated.
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Datasheet