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CTSK

CTSK (Cathepsin K) is a Protein Coding gene. Diseases associated with CTSK include Pycnodysostosis and Endosteal Hyperostosis, Autosomal Dominant. Among its related pathways are RANK Signaling in Osteoclasts and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and collagen binding. An important paralog of this gene is CTSS.
Full Name
Cathepsin K
Function
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).
Biological Process
Autophagy of mitochondrion Source: ParkinsonsUK-UCL
Collagen catabolic process Source: BHF-UCL
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Proteolysis Source: ProtInc
Proteolysis involved in cellular protein catabolic process Source: UniProtKB
Regulation of keratinocyte differentiation Source: Reactome
Thyroid hormone generation Source: UniProtKB
Toll-like receptor signaling pathway Source: Reactome
Cellular Location
Lysosome; Apical cell membrane; Secreted. Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.
Involvement in disease
Pycnodysostosis (PKND):
A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone.

Anti-CTSK antibodies

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Rabbit Anti-CTSK Recombinant Antibody (EP9403) (CBMAB-1493-CN)

Datasheet SDS
Target: CTSK
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EP9403
Application*: WB

Mouse Anti-CTSK Recombinant Antibody (CBLNC-141) (CBMAB-1492-CN)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLNC-141
Application*: E, WB, F, IF, P

Mouse Anti-CTSK Recombinant Antibody (3F9) (CBMAB-1491-CN)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3F9
Application*: E, F, P, IP, WB

Mouse Anti-CTSK Recombinant Antibody (CBCNC-485) (CBMAB-C3142-CN)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG
Specificity: Monkey
Clone: CBCNC-485
Application*: E, WB

Mouse Anti-CTSK Recombinant Antibody (CBWJC-3427) (CBMAB-C4651WJ)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBWJC-3427
Application*: WB, IC, P, IH-F, E, IP, IF, F

Mouse Anti-CTSK Recombinant Antibody (CBXC-0619) (CBMAB-C5054-CQ)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-0619
Application*: E, P, WB

Mouse Anti-CTSK Recombinant Antibody (CBXC-0620) (CBMAB-C3116-CQ)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-0620
Application*: E, IH, WB

Mouse Anti-CTSK Recombinant Antibody (CBXC-0621) (CBMAB-C3115-CQ)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0621
Application*: WB

Mouse Anti-CTSK (AA 220-329) Recombinant Antibody (CBFYC-2452) (CBMAB-C2525-FY)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-2452
Application*: E

Mouse Anti-CTSK Recombinant Antibody (CAP600) (CBMAB-AP1783LY)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Pig, Rat
Clone: CAP600
Application*: ICC, IHC, IP, WB

Mouse Anti-CTSK Recombinant Antibody (CAP599) (CBMAB-AP1782LY)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG
Specificity: Monkey
Clone: CAP599
Application*: ICC, IHC, IP, WB

Mouse Anti-CTSK Recombinant Antibody (CBLC202-LY) (CBMAB-C11329-LY)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLC202-LY
Application*: E, WB, P

Mouse Anti-CTSK Recombinant Antibody (CBLC201-LY) (CBMAB-C11328-LY)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLC201-LY
Application*: WB, E, P, F

Mouse Anti-CTSK Recombinant Antibody (CBCNC-486) (CBMAB-C3143-CN)

Datasheet SDS
Target: CTSK
Host: Mouse
Specificity: Human
Clone: CBCNC-486
Application*: WB, ICC, P, IH-F, E

Mouse Anti-CTSK Recombinant Antibody (CBCNC-484) (CBMAB-C3141-CN)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBCNC-484
Application*: E, P, WB

Mouse Anti-CTSK Recombinant Antibody (CBCNC-483) (CBMAB-C3140-CN)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBCNC-483
Application*: WB

Mouse Anti-CTSK Recombinant Antibody (10C464) (CBMAB-C3137-CN)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10C464
Application*: E, IH, WB

Mouse Anti-CTSK Recombinant Antibody (V2-186962) (CBMAB-C6698-LY)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-186962
Application*: C, WB

Mouse Anti-CTSK Recombinant Antibody (2F1) (CBMAB-C0882-LY)

Datasheet SDS
Target: CTSK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F1
Application*: E, C, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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