CTSK

CTSK (Cathepsin K) is a Protein Coding gene. Diseases associated with CTSK include Pycnodysostosis and Endosteal Hyperostosis, Autosomal Dominant. Among its related pathways are RANK Signaling in Osteoclasts and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and collagen binding. An important paralog of this gene is CTSS.

Cathepsin K

Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).

Autophagy of mitochondrion Source: ParkinsonsUK-UCL
Collagen catabolic process Source: BHF-UCL
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Proteolysis Source: ProtInc
Proteolysis involved in cellular protein catabolic process Source: UniProtKB
Regulation of keratinocyte differentiation Source: Reactome
Thyroid hormone generation Source: UniProtKB
Toll-like receptor signaling pathway Source: Reactome

Lysosome; Apical cell membrane; Secreted. Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.

Pycnodysostosis (PKND):
A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone.