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CXCR6

CXCR6 (C-X-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CXCR6 include Sarcoidosis 1 and Xanthogranulomatous Cholecystitis. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CCR7.

Full Name

C-X-C Motif Chemokine Receptor 6

Function

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Biological Process

Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Inflammatory response Source: InterPro
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Viral genome replication Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-32
Helical: 33-59
Cytoplasmic: 60-68
Helical: 69-89
Extracellular: 90-103
Helical: 104-125
Cytoplasmic: 126-143
Helical: 144-164
Extracellular: 165-187
Helical: 188-215
Cytoplasmic: 216-231
Helical: 232-259
Extracellular: 260-275
Helical: 276-293
Cytoplasmic: 294-342

Anti-CXCR6 antibodies

Mouse Anti-CXCR6 Recombinant Antibody (2B44) (CBMAB-C4694-LY)

SDS

Target: CXCR6

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 2B44

Application*: F

Mouse Anti-CXCR6 Recombinant Antibody (56811) (CBMAB-C7213-LY)

SDS

Target: CXCR6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 56811

Application*: F, MC

Mouse Anti-CXCR6 Recombinant Antibody (CBYY-C0331) (CBMAB-C1105-YY)

SDS

Target: CXCR6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C0331

Application*: F

Mouse Anti-CXCR6 Recombinant Antibody (11n52) (CBMAB-C3255-CN)

SDS

Target: CXCR6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 11n52

Application*: FC

Mouse Anti-CXCR6 Recombinant Antibody (14L333) (CBMAB-C3256-CN)

SDS

Target: CXCR6

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 14L333

Application*: FC, IH

Rat Anti-CXCR6 Recombinant Antibody (SA051D1) (CBMAB-C11422-LY)

SDS

Target: CXCR6

Host: Rat

Antibody Isotype: IgG2b, κ

Specificity: Mouse

Clone: SA051D1

Application*: F

Mouse Anti-CXCR6 Recombinant Antibody (MM0226-2B44) (CBMAB-C11421-LY)

SDS

Target: CXCR6

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: MM0226-2B44

Application*: F

Mouse Anti-CXCR6 Recombinant Antibody (PRO225) (CBMAB-C11423-LY)

SDS

Target: CXCR6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Rat

Clone: PRO225

Application*: IF, WB

Rat Anti-CXCR6 Recombinant Antibody (221002) (CBMAB-C0662-LY)

SDS

Target: CXCR6

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: 221002

Application*: F, MC

Rat Anti-CXCR6 Recombinant Antibody (14L334) (CBMAB-C3172-LY)

SDS

Target: CXCR6

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: 14L334

Application*: F

Mouse Anti-CXCR6 Recombinant Antibody (879112) (CBMAB-C9000-LY)

SDS

Target: CXCR6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: 879112

Application*: F, MC

Mouse Anti-CXCR6 Recombinant Antibody (CBFYC-2550) (CBMAB-C2624-FY)

SDS

Target: CXCR6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYC-2550

Application*: F

Mouse Anti-CXCR6 Recombinant Antibody (CBXC-2718) (CBMAB-C0936-CQ)

SDS

Target: CXCR6

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBXC-2718

Application*: F, C, MC

Human Anti-CXCR6 Recombinant Antibody (CBXC-0854) (CBMAB-C3633-CQ)

SDS

Target: CXCR6

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0854

Application*: F

Mouse Anti-CXCR6 Recombinant Antibody (CBWJC-3502) (CBMAB-C4733WJ)

SDS

Target: CXCR6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBWJC-3502

Application*: F

Rat Anti-CXCR6 Recombinant Antibody (CBFYC-0448) (CBMAB-C0494-FY)

SDS

Target: CXCR6

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBFYC-0448

Application*: F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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