CYP2J2

CYP2J2 (Cytochrome P450 Family 2 Subfamily J Member 2) is a Protein Coding gene. Diseases associated with CYP2J2 include Clopidogrel Resistance. Among its related pathways are Metabolism and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2D6.

Cytochrome P450 Family 2 Subfamily J Member 2

A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576).

Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576).

Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948).

In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933).

Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256).

Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307).

Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256).

Epoxygenase P450 pathway Source: UniProtKB
Exogenous drug catabolic process Source: GO_Central
Fatty acid metabolic process Source: Reactome
Icosanoid metabolic process Source: UniProtKB
Linoleic acid metabolic process Source: BHF-UCL
Organic acid metabolic process Source: GO_Central
Regulation of heart contraction Source: ProtInc
Xenobiotic metabolic process Source: GO_Central

Endoplasmic reticulum membrane; Microsome membrane