DAPK2

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq]

Full Name

death-associated protein kinase 2

Function

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302).

Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421).

Biological Process

Anoikis Source: UniProtKB
Apoptotic process Source: UniProtKB
Intracellular signal transduction Source: UniProtKB
Positive regulation of apoptotic process Source: GO_Central
Positive regulation of eosinophil chemotaxis Source: UniProtKB
Positive regulation of neutrophil chemotaxis Source: UniProtKB
Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of apoptotic process Source: UniProtKB
Regulation of autophagy Source: UniProtKB
Regulation of intrinsic apoptotic signaling pathway Source: UniProtKB

Cellular Location

Cytoplasm; Autophagosome lumen