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DLL4

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]
Full Name
Delta Like Canonical Notch Ligand 4
Function
Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954).

Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313).

Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity).

During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).
Biological Process
Angiogenesis Source: BHF-UCL
Aortic valve morphogenesis Source: BHF-UCL
Blood circulation Source: ProtInc
Blood vessel lumenization Source: Ensembl
Blood vessel remodeling Source: BHF-UCL
Branching involved in blood vessel morphogenesis Source: BHF-UCL
Cardiac atrium morphogenesis Source: BHF-UCL
Cardiac ventricle morphogenesis Source: BHF-UCL
Cellular response to fibroblast growth factor stimulus Source: UniProtKB
Cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
Dorsal aorta morphogenesis Source: BHF-UCL
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: UniProtKB
Negative regulation of cell migration involved in sprouting angiogenesis Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of endothelial cell migration Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Negative regulation of Notch signaling pathway Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Notch signaling involved in heart development Source: BHF-UCL
Notch signaling pathway Source: GO_Central
Pericardium morphogenesis Source: BHF-UCL
Positive regulation of gene expression Source: UniProtKB
Positive regulation of neural precursor cell proliferation Source: UniProtKB
Positive regulation of Notch signaling pathway Source: UniProtKB
Regulation of neural retina development Source: UniProtKB
Regulation of neurogenesis Source: Ensembl
Signal transduction Source: ProtInc
T cell differentiation Source: UniProtKB
Ventral spinal cord interneuron fate commitment Source: UniProtKB
Ventricular trabecula myocardium morphogenesis Source: BHF-UCL
Visual perception Source: UniProtKB-KW
Cellular Location
Cell membrane
Involvement in disease
Adams-Oliver syndrome 6 (AOS6):
A form of Adams-Oliver syndrome, a disorder characterized by the congenital absence of skin (aplasia cutis congenita) in combination with transverse limb defects. Aplasia cutis congenita can be located anywhere on the body, but in the vast majority of the cases, it is present on the posterior parietal region where it is often associated with an underlying defect of the parietal bones. Limb abnormalities are typically limb truncation defects affecting the distal phalanges or entire digits (true ectrodactyly). Only rarely, metatarsals/metacarpals or more proximal limb structures are also affected. Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed. The clinical features are highly variable and can also include cardiovascular malformations, brain abnormalities and vascular defects such as cutis marmorata and dilated scalp veins.
Topology
Extracellular: 27-529
Helical: 530-550
Cytoplasmic: 551-685

Anti-DLL4 antibodies

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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: DLL4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CP0472
Application*: E
Target: DLL4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E2
Application*: E, WB
Target: DLL4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCD-308
Application*: E
Target: DLL4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 11D36
Application*: IF, F
Target: DLL4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: D1097
Application*: E
Target: DLL4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: D1094
Application*: E
Target: DLL4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCD-308
Application*: WB
Target: DLL4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: D1092
Application*: F
Target: DLL4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D1091
Application*: E
Target: DLL4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: D1090
Application*: WB, IP, IF, E
Target: DLL4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G9A6
Application*: F
Target: DLL4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 15
Application*: E
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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