DYNLL1

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq]
Full Name
dynein, light chain, LC8-type 1
Research Area
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.

Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.

Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.

Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
Biological Process
Apoptotic process Source: UniProtKB-KW
Cilium assembly Source: GO_Central
Microtubule-based process Source: InterPro
Negative regulation of nitric oxide biosynthetic process Source: Ensembl
Negative regulation of phosphorylation Source: UniProtKB
Positive regulation of ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
Positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Spermatid development Source: Ensembl
Substantia nigra development Source: UniProtKB
Cellular Location
Mitochondrion; Centrosome; Cytoskeleton; Nucleus. Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.
PTM
Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.
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Anti-DYNLL1 antibodies

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Mouse Anti-DYNLL1 Recombinant Antibody (4/PIN) (CBMAB-P0287-YC)

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Target: DYNLL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 4/PIN
Application*: WB, IF
Datasheet SDS

Mouse Anti-DYNLL1 Recombinant Antibody (1H7) (CBMAB-D2006-YC)

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Target: DYNLL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H7
Application*: E, IF, WB
Datasheet SDS

Rat Anti-DYNLL1 Recombinant Antibody (10D6) (CBMAB-D2005-YC)

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Target: DYNLL1
Host: Rat
Antibody Isotype: IgM
Specificity: Human, Mouse
Clone: 10D6
Application*: F, WB
Datasheet SDS

Rabbit Anti-DYNLL1 Recombinant Antibody (CBYCD-461) (CBMAB-D2004-YC)

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Target: DYNLL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Drosophila
Clone: CBYCD-461
Application*: WB, P, IC, IP, IC, IF
Datasheet SDS

Mouse Anti-DYNLL1 Monoclonal Antibody (AT13C9) (CBMAB-1097-YC)

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Target: DYNLL1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: AT13C9
Application*: F, IC, IF, WB
Datasheet SDS

Rabbit Anti-DYNLL1 Monoclonal Antibody (EP1660Y) (CBMAB-1096-YC)

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Target: DYNLL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Drosophila
Clone: EP1660Y
Application*: F, IC, IF, P, IP, WB
Datasheet SDS

Mouse Anti-DYNLL1 Recombinant Antibody (P0287) (V2LY-0425-LY1146)

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Target: DYNLL1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: P0287
Application*: WB, IF, E, F
Datasheet SDS

Mouse Anti-DYNLL1 Recombinant Antibody (D2006) (V2LY-0425-LY1145)

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Target: DYNLL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: D2006
Application*: IP, IF, WB
Datasheet SDS

Mouse Anti-DYNLL1 Recombinant Antibody (D2005) (V2LY-0425-LY1144)

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Target: DYNLL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D2005
Application*: WB, IP
Datasheet SDS

Mouse Anti-DYNLL1 Recombinant Antibody (CBYCD-461) (V2LY-0425-LY1143)

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Target: DYNLL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCD-461
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-DYNLL1 Recombinant Antibody (1097) (V2LY-0425-LY1142)

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Target: DYNLL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 1097
Application*: IF, IH, F, WB
Datasheet SDS

Rabbit Anti-DYNLL1 Recombinant Antibody (1096) (V2LY-0425-LY1141)

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Target: DYNLL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 1096
Application*: IF, P, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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