EEF2

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
Full Name
Eukaryotic Translation Elongation Factor 2
Research Area
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Biological Process
Aging Source: Ensembl
Cellular response to brain-derived neurotrophic factor stimulus Source: Ensembl
Glial cell proliferation Source: Ensembl
Hematopoietic progenitor cell differentiation Source: Ensembl
Positive regulation of cytoplasmic translation Source: Ensembl
Positive regulation of translation Source: UniProtKB
Response to drug Source: Ensembl
Response to endoplasmic reticulum stress Source: Ensembl
Response to estradiol Source: Ensembl
Response to ethanol Source: Ensembl
Response to folic acid Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to ischemia Source: Ensembl
Skeletal muscle cell differentiation Source: Ensembl
Skeletal muscle contraction Source: Ensembl
Translational elongation Source: GO_Central
Cellular Location
Nucleus; Cytoplasm. Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product.
Involvement in disease
Spinocerebellar ataxia 26 (SCA26):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord.
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Anti-EEF2 antibodies

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Target: EEF2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP665
Application*: WB
Target: EEF2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP664
Application*: ELISA, WB
Target: EEF2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP663
Application*: ELISA, WB
Target: EEF2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CB423A
Application*: ELISA, WB
Target: EEF2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 11B2
Application*: E, WB
Target: EEF2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT462
Application*: WB, P, IF, IC, E
Target: EEF2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT463
Application*: WB
Target: EEF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3270
Application*: WB, IH, IC
Target: EEF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle
Clone: EG1033
Application*: WB
Target: EEF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP665
Application*: F, IF, WB
Target: EEF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CAP664
Application*: F, IF, P, WB
Target: EEF2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CAP663
Application*: WB, IP, IF, E, P
Target: EEF2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig, Chicken
Clone: CB423A
Application*: WB, IP, IF, E, P
Target: EEF2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0471
Application*: WB, IP, IF, E, P
Target: EEF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0470
Application*: E, IH, WB
Target: EEF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYE-0469
Application*: F, IF, P, WB
Target: EEF2
Host: Mouse
Specificity: Human
Clone: CBFYE-0471
Application*: WB
Target: EEF2
Host: Mouse
Specificity: Human
Clone: CBFYE-0470
Application*: P, WB
Target: EEF2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0469
Application*: E, IF, P, WB
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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