EEF2

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]

Eukaryotic Translation Elongation Factor 2

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

Aging Source: Ensembl
Cellular response to brain-derived neurotrophic factor stimulus Source: Ensembl
Glial cell proliferation Source: Ensembl
Hematopoietic progenitor cell differentiation Source: Ensembl
Positive regulation of cytoplasmic translation Source: Ensembl
Positive regulation of translation Source: UniProtKB
Response to drug Source: Ensembl
Response to endoplasmic reticulum stress Source: Ensembl
Response to estradiol Source: Ensembl
Response to ethanol Source: Ensembl
Response to folic acid Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to ischemia Source: Ensembl
Skeletal muscle cell differentiation Source: Ensembl
Skeletal muscle contraction Source: Ensembl
Translational elongation Source: GO_Central

Nucleus; Cytoplasm. Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product.

Spinocerebellar ataxia 26 (SCA26):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord.

Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.
Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine (By similarity).
(Microbial infection) Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus arresting protein synthesis.
ISGylated.
Proteolytically processed at two sites following phosphorylation by CSK.
SUMOylated following phosphorylation by CSK, promotes proteolytic cleavage.