EMILIN1

This gene encodes an extracellular matrix glycoprotein that is characterized by an N-terminal microfibril interface domain, a coiled-coiled alpha-helical domain, a collagenous domain and a C-terminal globular C1q domain. The encoded protein associates with elastic fibers at the interface between elastin and microfibrils and may play a role in the development of elastic tissues including large blood vessels, dermis, heart and lung. [provided by RefSeq, Sep 2009]

Elastin Microfibril Interfacer 1

May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.

Aortic valve morphogenesis Source: BHF-UCL
Cell adhesion Source: ProtInc
Cell-matrix adhesion Source: CAFA
Cell migration Source: CAFA
Elastic fiber assembly Source: BHF-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of cell activation Source: BHF-UCL
Negative regulation of collagen biosynthetic process Source: BHF-UCL
Negative regulation of collagen fibril organization Source: BHF-UCL
Negative regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Negative regulation of gene expression Source: BHF-UCL
Negative regulation of macrophage migration Source: BHF-UCL
Negative regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of cell-substrate adhesion Source: Ensembl
Positive regulation of extracellular matrix assembly Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL

Extracellular matrix. Found mainly at the interface between amorphous elastin and microfibrils.