EREG

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]

Epiregulin

Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975).

Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).

Anatomical structure morphogenesis Source: UniProtKB
Angiogenesis Source: UniProtKB-KW
Animal organ morphogenesis Source: UniProtKB
Cell-cell signaling Source: UniProtKB
Cytokine-mediated signaling pathway Source: UniProtKB
Epidermal growth factor receptor signaling pathway Source: UniProtKB
Female meiotic nuclear division Source: UniProtKB
Keratinocyte differentiation Source: UniProtKB
Keratinocyte proliferation Source: UniProtKB
Luteinizing hormone signaling pathway Source: UniProtKB
mRNA transcription Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of epithelial cell proliferation Source: UniProtKB
Negative regulation of smooth muscle cell differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Oocyte maturation Source: UniProtKB
Ovarian cumulus expansion Source: UniProtKB
Ovulation Source: UniProtKB
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of DNA replication Source: UniProtKB
Positive regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
Positive regulation of fibroblast proliferation Source: UniProtKB
Positive regulation of innate immune response Source: UniProtKB
Positive regulation of interleukin-6 production Source: UniProtKB
Positive regulation of mitotic nuclear division Source: UniProtKB
Positive regulation of phosphorylation Source: UniProtKB
Positive regulation of protein kinase activity Source: UniProtKB
Positive regulation of smooth muscle cell proliferation Source: UniProtKB
Primary follicle stage Source: UniProtKB
Response to peptide hormone Source: Ensembl
Wound healing Source: UniProtKB

Epiregulin: Extracellular space
Proepiregulin: Cell membrane

Extracellular: 60-119
Helical: 120-140
Cytoplasmic: 141-169