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FOXD3

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1.
Full Name
forkhead box D3
Function
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.
Biological Process
Anatomical structure morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
In utero embryonic development Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Autoimmune disease 1 (AIS1):
An autoimmune disorder characterized by the association of vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis).

Anti-FOXD3 antibodies

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Target: FOXD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBXF-0837
Application*: E, WB
Target: FOXD3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXF-1773
Application*: WB, IP, IF, P, E
Target: FOXD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse
Clone: CBXF-1603
Application*: E, IH, WB
Target: FOXD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse
Clone: CBXF-1602
Application*: E, WB
Target: FOXD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBXF-3736
Application*: E, WB, P, IF, F
Target: FOXD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2251
Application*: WB
Target: FOXD3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-2660
Application*: IC
Target: FOXD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: 5G9
Application*: E, WB
Target: FOXD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: B.81.8
Application*: WB
Target: FOXD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: 3D11-E3-G3
Application*: WB, IH
Target: FOXD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D20A9
Application*: WB
Target: FOXD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5G9
Application*: WB, IHC
Target: FOXD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 2A11G9, 2A11C2
Application*: WB, IHC
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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