GAS6

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

Growth Arrest Specific 6

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

(Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828).

Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921).

Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828).

Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).

Activation of protein kinase B activity Source: UniProtKB
Animal organ regeneration Source: Ensembl
Apoptotic cell clearance Source: UniProtKB
B cell chemotaxis Source: UniProtKB
Blood coagulation Source: Ensembl
Calcium ion transmembrane transport Source: UniProtKB
Cell-substrate adhesion Source: Ensembl
Cellular response to drug Source: UniProtKB
Cellular response to glucose stimulus Source: UniProtKB
Cellular response to growth factor stimulus Source: Ensembl
Cellular response to interferon-alpha Source: UniProtKB
Cellular response to starvation Source: Ensembl
Cellular response to vitamin K Source: UniProtKB
Dendritic cell differentiation Source: UniProtKB
Enzyme linked receptor protein signaling pathway Source: Ensembl
Extracellular matrix assembly Source: UniProtKB
Fusion of virus membrane with host plasma membrane Source: UniProtKB
Hematopoietic stem cell migration to bone marrow Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of biomineral tissue development Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Negative regulation of dendritic cell apoptotic process Source: UniProtKB
Negative regulation of DNA-binding transcription factor activity Source: UniProtKB
Negative regulation of endothelial cell apoptotic process Source: UniProtKB
Negative regulation of fibroblast apoptotic process Source: UniProtKB
Negative regulation of interferon-gamma production Source: UniProtKB
Negative regulation of interleukin-1 production Source: UniProtKB
Negative regulation of interleukin-6 production Source: UniProtKB
Negative regulation of oligodendrocyte apoptotic process Source: UniProtKB
Negative regulation of renal albumin absorption Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: UniProtKB
Neuron migration Source: Ensembl
Peptidyl-serine phosphorylation Source: UniProtKB
Phagocytosis Source: UniProtKB
Positive regulation of cytokine-mediated signaling pathway Source: UniProtKB
Positive regulation of dendritic cell chemotaxis Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: MGI
Positive regulation of fibroblast proliferation Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of glomerular filtration Source: UniProtKB
Positive regulation of natural killer cell differentiation Source: UniProtKB
Positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
Positive regulation of phagocytosis Source: UniProtKB
Positive regulation of protein export from nucleus Source: UniProtKB
Positive regulation of protein kinase activity Source: UniProtKB
Positive regulation of protein kinase B signaling Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Positive regulation of protein tyrosine kinase activity Source: UniProtKB
Positive regulation of TOR signaling Source: UniProtKB
Protein kinase B signaling Source: UniProtKB
Protein localization to plasma membrane Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Receptor-mediated virion attachment to host cell Source: UniProtKB
Regulation of growth Source: UniProtKB-KW
Signal transduction Source: UniProtKB
Viral entry into host cell Source: UniProtKB
Viral genome replication Source: UniProtKB

Secreted

Isoform 2:
Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.