ICAM3
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Full Name
Intercellular Adhesion Molecule 3
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173).
ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Biological Process
Cell adhesion Source: GO_Central
Cell-cell adhesion Source: InterPro
Phagocytosis Source: UniProtKB-KW
Cell-cell adhesion Source: InterPro
Phagocytosis Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Extracellular: 30-485
Helical: 486-510
Cytoplasmic: 511-547
Helical: 486-510
Cytoplasmic: 511-547
PTM
Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.
N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.
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Anti-ICAM3 antibodies
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CompareTarget: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A366
Application*: ELISA, FC, IF, IHC, IP, RIA, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A369
Application*: ELISA, FC, ICC, IHC, IP, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A368
Application*: ELISA, FC, ICC, IHC, IP, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A367
Application*: ELISA, FC, IF, IHC, IP, RIA, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: A365
Application*: FC, IHC, IP, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A364
Application*: FC, IHC, IP
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A363
Application*: FC, IP
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A362
Application*: ELISA, FC, ICC, IHC, IP, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: BRIC 79
Application*: ELISA, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D2
Application*: FC, IF, IHC
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: YUK2
Application*: F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9L96
Application*: FC, IP
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D37
Application*: FC, IH
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3788
Application*: IP, WB, IC, E, C, F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3787
Application*: F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3786
Application*: E
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3785
Application*: IP, F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3784
Application*: E
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3782
Application*: IP, WB, IC, E, C, F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBR-IC3/1
Application*: F, IH, IP, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CG106
Application*: F, IH, IP, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: By44
Application*: F, IH, IP
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BU65
Application*: F, IP
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3.1
Application*: E, F, IH, IF, IP, R, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1854
Application*: F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-2456
Application*: F, IH, IF, B
Target: ICAM3
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0945
Application*: F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2547
Application*: F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C2546
Application*: F, IH
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2545
Application*: E, F, IH
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2544
Application*: IC, IH
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2543
Application*: F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0523
Application*: F, IH
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2749
Application*: F, IF, C
Target: ICAM3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2748
Application*: E
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2747
Application*: N, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0347
Application*: F, P
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0731
Application*: WB, BL
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 7H110
Application*: F, IH
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A309
Application*: F, IH
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F74
Application*: IC, IH
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B26
Application*: F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2F8
Application*: WB, P
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L218
Application*: N, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 101-1D2
Application*: F, IF, C
Target: ICAM3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 101
Application*: E
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 186-2G9
Application*: C, F, IC/IF, IP, P, WB
Target: ICAM3
Sensitivity: 0.41 ng/mL
Detection Range: 1-400 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: ICAM3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-485
Tag: His Tag
Target: ICAM3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-485
Tag: His & hFc Tag
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4334
Application*: F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3254
Application*: F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I2102
Application*: WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey, Mouse
Clone: CBYY-I2090
Application*: WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1935
Application*: WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog
Clone: CBYY-I1934
Application*: WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: CBYY-I1931
Application*: WB, IH, IF
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1907
Application*: WB, IH, IF
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1861
Application*: WB, IP, E, P, R, C, F, IF
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1621
Application*: E, F, FN, C, N
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1619
Application*: WB, F, MC
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I1601
Application*: E
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1370
Application*: N, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: BH10
Application*: E, WB, C, IF, IP, F
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0536
Application*: WB, F, BL, MC
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0522
Application*: F, IH, IP, MC
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: SPM505
Application*: WB, F, E, IF, IP, P, C, MC, BL
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-171
Application*: F, IP
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: ICAM3/1019
Application*: WB, F, P, IF, MC
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: ICAM3.1
Application*: E, F, C, IP, R, WB
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0087
Application*: WB, F, IH, IP, MC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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