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ICAM3

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Full Name
Intercellular Adhesion Molecule 3
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173).

ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Biological Process
Cell adhesion Source: GO_Central
Cell-cell adhesion Source: InterPro
Phagocytosis Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Extracellular: 30-485
Helical: 486-510
Cytoplasmic: 511-547
PTM
Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.

Anti-ICAM3 antibodies

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Mouse Anti-ICAM3 Recombinant Antibody (CBWJC-3788) (CBMAB-C5055WJ)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3788
Application*: IP, WB, IC, E, C, F

Mouse Anti-ICAM3 Recombinant Antibody (CBWJC-3787) (CBMAB-C5054WJ)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3787
Application*: F

Mouse Anti-ICAM3 Recombinant Antibody (CBWJC-3786) (CBMAB-C5053WJ)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3786
Application*: E

Mouse Anti-ICAM3 Recombinant Antibody (CBWJC-3785) (CBMAB-C5052WJ)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3785
Application*: IP, F

Mouse Anti-ICAM3 Recombinant Antibody (CBWJC-3784) (CBMAB-C5051WJ)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3784
Application*: E

Mouse Anti-ICAM3 Recombinant Antibody (CBWJC-3782) (CBMAB-C5049WJ)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3782
Application*: IP, WB, IC, E, C, F

Mouse Anti-ICAM3 Recombinant Antibody (CBR-IC3/1) (CBMAB-C2951WJ)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBR-IC3/1
Application*: F, IH, IP, WB

Mouse Anti-ICAM3 Recombinant Antibody (CBXC-1854) (CBMAB-C4884-CQ)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1854
Application*: F

Mouse Anti-ICAM3 Recombinant Antibody (CBXC-2456) (CBMAB-C4883-CQ)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-2456
Application*: F, IH, IF, B

Human Anti-ICAM3 Recombinant Antibody (CBXC-0945) (CBMAB-C2061-CQ)

Datasheet SDS
Target: ICAM3
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0945
Application*: F

Mouse Anti-ICAM3 Recombinant Antibody (CBFYC-2749) (CBMAB-C2824-FY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2749
Application*: F, IF, C

Rabbit Anti-ICAM3 Recombinant Antibody (CBFYC-2748) (CBMAB-C2823-FY)

Datasheet SDS
Target: ICAM3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2748
Application*: E

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I0731) (CBMAB-I1632-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0731
Application*: WB, BL

Mouse Anti-ICAM3 Recombinant Antibody (CBFYC-2747) (CBMAB-C2822-FY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2747
Application*: N, WB

Mouse Anti-ICAM3 Recombinant Antibody (CBFYC-0347) (CBMAB-C0386-FY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0347
Application*: F, P

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I2102) (CBMAB-I3272-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I2102
Application*: WB

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I2090) (CBMAB-I3260-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey, Mouse
Clone: CBYY-I2090
Application*: WB

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I1935) (CBMAB-I3105-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1935
Application*: WB

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I1934) (CBMAB-I3104-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog
Clone: CBYY-I1934
Application*: WB

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I1931) (CBMAB-I3101-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: CBYY-I1931
Application*: WB, IH, IF

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I1907) (CBMAB-I3077-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1907
Application*: WB, IH, IF

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I1861) (CBMAB-I3031-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1861
Application*: WB, IP, E, P, R, C, F, IF

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I1621) (CBMAB-I2791-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1621
Application*: E, F, FN, C, N

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I1619) (CBMAB-I2789-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1619
Application*: WB, F, MC

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I1601) (CBMAB-I2771-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I1601
Application*: E

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I1370) (CBMAB-I2540-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1370
Application*: N, WB

Mouse Anti-ICAM3 Recombinant Antibody (BH10) (CBMAB-I2016-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: BH10
Application*: E, WB, C, IF, IP, F

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I0536) (CBMAB-I1217-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0536
Application*: WB, F, BL, MC

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I0522) (CBMAB-I1196-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0522
Application*: F, IH, IP, MC

Mouse Anti-ICAM3 Recombinant Antibody (SPM505) (CBMAB-I1096-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: SPM505
Application*: WB, F, E, IF, IP, P, C, MC, BL

Mouse Anti-ICAM3 Recombinant Antibody (MEM-171) (CBMAB-I0847-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-171
Application*: F, IP

Mouse Anti-ICAM3 Recombinant Antibody (ICAM3/1019) (CBMAB-I0225-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: ICAM3/1019
Application*: WB, F, P, IF, MC

Mouse Anti-ICAM3 Recombinant Antibody (ICAM3.1) (CBMAB-I0223-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: ICAM3.1
Application*: E, F, C, IP, R, WB

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I0087) (CBMAB-I0222-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0087
Application*: WB, F, IH, IP, MC

Mouse Anti-ICAM3 Recombinant Antibody (A369) (CBMAB-AP3544LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A369
Application*: ELISA, FC, ICC, IHC, IP, WB

Mouse Anti-ICAM3 Recombinant Antibody (A368) (CBMAB-AP3522LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A368
Application*: ELISA, FC, ICC, IHC, IP, WB

Mouse Anti-ICAM3 Recombinant Antibody (A367) (CBMAB-AP3553LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A367
Application*: ELISA, FC, IF, IHC, IP, RIA, WB

Mouse Anti-ICAM3 Recombinant Antibody (A366) (CBMAB-AP3551LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A366
Application*: ELISA, FC, IF, IHC, IP, RIA, WB

Mouse Anti-ICAM3 Recombinant Antibody (A365) (CBMAB-AP3539LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: A365
Application*: FC, IHC, IP, WB

Mouse Anti-ICAM3 Recombinant Antibody (A364) (CBMAB-AP3536LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A364
Application*: FC, IHC, IP

Mouse Anti-ICAM3 Recombinant Antibody (A363) (CBMAB-AP3540LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A363
Application*: FC, IP

Mouse Anti-ICAM3 Recombinant Antibody (A362) (CBMAB-AP3523LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A362
Application*: ELISA, FC, ICC, IHC, IP, WB

Mouse Anti-ICAM3 Recombinant Antibody (BRIC 79) (CBMAB-AP1166LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: BRIC 79
Application*: ELISA, WB

Mouse Anti-ICAM3 Recombinant Antibody (1D2) (CBMAB-AP1163LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D2
Application*: FC, IF, IHC

Mouse Anti-ICAM3 Recombinant Antibody (YUK2) (CBMAB-C11658-LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: YUK2
Application*: F

Mouse Anti-ICAM3 Recombinant Antibody (9L96) (CBMAB-C3583-CN)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9L96
Application*: FC, IP

Mouse Anti-ICAM3 Recombinant Antibody (6D37) (CBMAB-C3582-CN)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D37
Application*: FC, IH

Recombinant Mouse Anti-ICAM3 Recombinant Antibody (CG106) (CBMAB-XB0581-YC)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CG106
Application*: F, IH, IP, WB

Recombinant Mouse Anti-ICAM3 Recombinant Antibody (By44) (CBMAB-XB0580-YC)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: By44
Application*: F, IH, IP

Recombinant Mouse Anti-ICAM3 Recombinant Antibody (BU65) (CBMAB-XB0579-YC)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BU65
Application*: F, IP

Recombinant Mouse Anti-ICAM3 Recombinant Antibody (3.1) (CBMAB-XB0577-YC)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3.1
Application*: E, F, IH, IF, IP, R, WB

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-C2547) (CBMAB-C3988-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2547
Application*: F

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-C2546) (CBMAB-C3987-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C2546
Application*: F, IH

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-C2545) (CBMAB-C3986-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2545
Application*: E, F, IH

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-C2544) (CBMAB-C3985-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2544
Application*: IC, IH

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-C2543) (CBMAB-C3984-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2543
Application*: F

Mouse Anti-ICAM3 Recombinant Antibody (CBYY-C0523) (CBMAB-C1563-YY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0523
Application*: F, IH

Mouse Anti-ICAM3 Recombinant Antibody (7H110) (CBMAB-C8754-LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 7H110
Application*: F, IH

Mouse Anti-ICAM3 Recombinant Antibody (6A309) (CBMAB-C8010-LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A309
Application*: F, IH

Mouse Anti-ICAM3 Recombinant Antibody (5F74) (CBMAB-C7637-LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F74
Application*: IC, IH

Mouse Anti-ICAM3 Recombinant Antibody (5B26) (CBMAB-C7311-LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B26
Application*: F

Mouse Anti-ICAM3 Recombinant Antibody (2F8) (CBMAB-C5126-LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2F8
Application*: WB, P

Mouse Anti-ICAM3 Recombinant Antibody (14L218) (CBMAB-C3125-LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L218
Application*: N, WB

Mouse Anti-ICAM3 Recombinant Antibody (101-1D2) (CBMAB-C2028-LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 101-1D2
Application*: F, IF, C

Rabbit Anti-ICAM3 Recombinant Antibody (101) (CBMAB-C2022-LY)

Datasheet SDS
Target: ICAM3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 101
Application*: E

Mouse Anti-ICAM3 Recombinant Antibody (186-2G9) (CBMAB-C0444-LY)

Datasheet SDS
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 186-2G9
Application*: C, F, IC/IF, IP, P, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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