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IDS

This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Full Name

Iduronate 2-Sulfatase

Function

Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.

Biological Process

Glycosaminoglycan catabolic process Source: UniProtKB

Cellular Location

Lysosome

Involvement in disease

Mucopolysaccharidosis 2 (MPS2):
An X-linked lysosomal storage disease characterized by intracellular accumulation of heparan sulfate and dermatan sulfate and their excretion in urine. Most children with MPS2 have a severe form with early somatic abnormalities including skeletal deformities, hepatosplenomegaly, and progressive cardiopulmonary deterioration. A prominent feature is neurological damage that presents as developmental delay and hyperactivity but progresses to mental retardation and dementia. They die before 15 years of age, usually as a result of obstructive airway disease or cardiac failure. In contrast, those with a mild form of MPS2 may survive into adulthood, with attenuated somatic complications and often without mental retardation.

PTM

Synthesized as a 75-kDa precursor form in the endoplasmic reticulum (ER), and then processed by proteolytic cleavage through various intermediates to yield a 55-kDa mature form, with the release of an 18 kDa polypeptide.
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

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Anti-IDS antibodies

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Mouse Anti-IDS Recombinant Antibody (CBYY-I2089) (CBMAB-I3259-YY)

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Target: IDS

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Dog, Rat, Monkey, Mouse

Clone: CBYY-I2089

Application*: WB, IH, IF, F

Mouse Anti-IDS Recombinant Antibody (A384) (CBMAB-AP10812LY)

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Target: IDS

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: A384

Application*: ELISA, IF, IHC, WB

Mouse Anti-IDS Recombinant Antibody (CBYY-I2021) (CBMAB-I3191-YY)

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Target: IDS

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-I2021

Application*: WB, IH, IF, F

Mouse Anti-IDS Recombinant Antibody (CBYY-I1922) (CBMAB-I3092-YY)

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Target: IDS

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBYY-I1922

Application*: WB, IH, IF, F

Mouse Anti-IDS Recombinant Antibody (4G2) (CBMAB-I1348-YY)

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Target: IDS

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Dog, Rat, Monkey, Mouse

Clone: 4G2

Application*: WB, F, IH, IF, P

Mouse Anti-IDS Recombinant Antibody (1D9) (CBMAB-I0252-YY)

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Target: IDS

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: 1D9

Application*: IF, F, IH, WB, P

Human Recombinant IDS protein, His Tag (V2LY-0526-LY4642)

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Target: IDS

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-550

Tag: His Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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