IL17RA

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.

interleukin 17 receptor A

Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539).

Receptor for IL17F (PubMed:19838198, PubMed:17911633).

Binds to IL17A with higher affinity than to IL17F (PubMed:17911633).

Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495).

Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971).

Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:24120361, PubMed:17911633, PubMed:18684971, PubMed:21350122).

Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity).

In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity).

Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity).

Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity).

Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848).

(Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway.

Cell surface receptor signaling pathway Source: UniProtKB
Defense response to fungus Source: Ensembl
Fibroblast activation Source: BHF-UCL
Granulocyte chemotaxis Source: Ensembl
Inflammatory response Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Interleukin-17-mediated signaling pathway Source: UniProtKB
Positive regulation of chemokine (C-X-C motif) ligand 1 production Source: UniProtKB
Positive regulation of cytokine production involved in inflammatory response Source: UniProtKB
Positive regulation of inflammatory response Source: UniProtKB
Positive regulation of interleukin-13 production Source: Ensembl
Positive regulation of interleukin-23 production Source: BHF-UCL
Positive regulation of interleukin-5 production Source: Ensembl
Positive regulation of interleukin-6 production Source: UniProtKB
Protein catabolic process Source: Ensembl
Response to virus Source: UniProtKB
T-helper 17 type immune response Source: Ensembl

Isoform 1: Cell membrane
Isoform 2: Secreted

Immunodeficiency 51 (IMD51):
A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

Extracellular: 33-320
Helical: 321-341
Cytoplasmic: 342-866

Glycosylated.