JUN

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

Full Name

Jun proto-oncogene, AP-1 transcription factor subunit

Function

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952).

Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646).

Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306).

Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

Biological Process

Aging Source: Ensembl
Angiogenesis Source: Ensembl
Cellular response to cadmium ion Source: CAFA
Cellular response to potassium ion starvation Source: Ensembl
Cellular response to reactive oxygen species Source: CAFA
Circadian rhythm Source: Ensembl
Fc-epsilon receptor signaling pathway Source: Reactome
Learning Source: Ensembl
Membrane depolarization Source: Ensembl
Negative regulation by host of viral transcription Source: UniProtKB
Negative regulation of DNA binding Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Positive regulation by host of viral transcription Source: UniProtKB
Positive regulation of apoptotic process Source: CAFA
Positive regulation of DNA replication Source: Ensembl
Positive regulation of DNA-templated transcription, initiation Source: CACAO
Positive regulation of monocyte differentiation Source: Ensembl
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Ras protein signal transduction Source: UniProtKB
Regulation of cell cycle Source: GO_Central
Regulation of cell population proliferation Source: GO_Central
Regulation of DNA-binding transcription factor activity Source: Reactome
Regulation of transcription by RNA polymerase II Source: GO_Central
Release of cytochrome c from mitochondria Source: Ensembl
Response to cAMP Source: Ensembl
Response to cytokine Source: Ensembl
Response to drug Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to radiation Source: Ensembl
SMAD protein signal transduction Source: BHF-UCL
Transcription by RNA polymerase II Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: BHF-UCL

Cellular Location

Nucleus

PTM

Ubiquitinated by the SCF(FBXW7), leading to its degradation (PubMed:14739463, PubMed:27458189). Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7 (PubMed:14739463).
Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.
Acetylated at Lys-271 by EP300.